Objective: To discuss the application of portal vein embolization in two-stage precise hepatectomy. Methods: Clinical data of 7 patients who underwent two-stage precise hepatectomy after percutaneous transhepatic portal vein embolization guided by ultrasound and digital subtraction angiography were analyzed in this study. There were 3 cases in liver cirrhosis group and 4 cases in without liver cirrhosis group. Liver function and liver volume were detected in each group before and after portal vein embolization, and the effect of two-stage surgical resection was examined. Results: Percutaneous transhepatic portal vein embolization was successfully performed in all 7 patients. Future liver remnant increased and hepatic hypertrophy was found in 6 patients who completed two-stage precise hepatectomy afterward. Non-embolized liver hypertrophy was not enough to the conditions for two-stage hepatectomy after 8 weeks in the other patient of colorectal cancer with liver metastases. The patient underwent the therapy of associating liver partition and portal vein ligation for staged hepatectomy in other hospital. In both groups liver function was abnormal at the first day after the percutaneous transhepatic portal vein embolization (P<0.05) and recovered to normal 3-7 days later. No severe complication was found in this study. Conclusions: Portal vein embolization is safe and feasible, and increases the volume of future liver remnant significantly. It can provide the opportunity of two-stage precise hepatectomy.
JIN Shengjie, FAN Yiqun, BAI Dousheng, JIANG Guoqing, QIAN Jianjun, YAO Jie, WANG Xiaodong, GAO Zhihui, ZHANG Chi
. Experience of portal vein embolization for two-stage precise hepatectomy[J]. Journal of Surgery Concepts & Practice, 2018
, 23(03)
: 247
-251
.
DOI: 10.16139/j.1007-9610.2018.03.013
[1] Huang B, Yu Y, Zhao S, et al.Precise hepatectomy based on the optimized technique of hepatic blood flow occlusion combined with the curettage and cut technique by electrotome[J]. Minerva Chir,2016,72(1):1-9.
[2] 徐安书, 傅朝春, 韦萍, 等. 3D打印技术在精准切除治疗肝脏肿瘤中的应用[J]. 中国普通外科杂志,2018,27(1):29-34.
[3] Kinoshita H, Sakai K, Hirohashi K, et al.Preoperative portal vein embolization for hepatocellular carcinoma[J]. World J Surg,1986,10(5):803-808.
[4] Makuuchi M, Thai BL, Takayasu K, et al.Preoperative portal embolization to increase safety of major hepatectomy for hilar bile duct carcinoma: a preliminary report[J]. Surgery,1990,107(5):521-527.
[5] Orcutt ST, Kobayashi K, Sultenfuss M, et al.Portal vein embolization as an oncosurgical strategy prior to major hepatic resection: anatomic, surgical, and technical considerations[J]. Front Surg,2016,3:14.
[6] Wu H, Zeng Y, Li J, et al.Application of PVE in hepatic surgery[M]//Yan L. Operative Techniques in Liver Resection. Dordrecht: Springer Netherlands,2016:245-248.
[7] Rous P, Larimore LD.Relation of the portal blood to li-ver maintenance: a demonstration of liver atrophy conditional on compensation[J]. J Exp Med,1920,31(5):609-632.
[8] Madoff DC, Hicks ME, Abdalla EK, et al.Portal vein embolization with polyvinyl alcohol particles and coils in preparation for major liver resection for hepatobiliary malignancy: safety and effectiveness--study in 26 patients[J]. Radiology,2003,227(1):251-260.
[9] de Baere T, Roche A, Elias D, et al. Preoperative portal vein embolization for extension of hepatectomy indications[J]. Hepatology,1996,24(6):1386-1391.
[10] Tsuge H, Mimura H, Kawata N, et al.Right portal embolization before extended right hepatectomy using laparoscopic catheterization of the ileocolic vein: a prospective study[J]. Surg Laparosc Endosc,1994,4(4):258-263.
[11] Matela J, Zabavnik Z, Jukic T, et al.Selective portal vein embolization as introduction in major surgery[J]. Coll Antropol,2005,29(1):163-167.
[12] Takayama T, Makuuchi M.Preoperative portal vein embolization: is it useful?[J]. J Hepatobiliary Pancreat Surg,2004,11(1):17-20.
[13] Gruttadauria S, Luca A, Mandala L, et al.Sequential preoperative ipsilateral portal and arterial embolization in patients with colorectal liver metastases[J]. World J Surg,2006,30(4):576-578.
[14] 荚卫东. 精准肝切除治疗肝细胞癌关键技术[J]. 中国普通外科杂志,2014,23(1):1-5.
[15] Yokoyama Y, Ebata T, Igami T, et al.The predictive va-lue of indocyanine green clearance in future liver remnant for posthepatectomy liver failure following hepatectomy with extrahepatic bile duct resection[J]. World J Surg,2016,40(6):1440-1447.
[16] Lodge JPA.Taking “Play-Doh” to the kids: using the ALPPS approach to prevent postoperative liver failure[J]. Ann Surg,2017,266(2):e18.
[17] 周俭, 王征, 孙健, 等. 联合肝脏离断和门静脉结扎的二步肝切除术[J]. 中华消化外科杂志,2013,12(7):485-489.
[18] Ratti F, Schadde E, Masetti M, et al.Strategies to increase the resectability of patients with colorectal liver metastases: a multi-center case-match analysis of ALPPS and conventional two-stage hepatectomy[J]. Ann Surg Oncol,2015,22(6):1933-1942.
[19] 张宁, 卢实春, 冯玉泉. 联合肝实质离断及门静脉结扎的分期肝切除术研究进展[J]. 中华肝胆外科杂志,2015,21(6):421-423.
[20] Wu H, Pan G.Associating liver partition and portal vein ligation for staged hepatectomy[M]//Yan L. Operative Techniques in Liver Resection. Dordrecht: Springer Netherlands,2016:249-254.