Objective To compare clinical results in gastric cancer patients with radical gastrectomy among 3D laparoscopy, 2D laparoscopy and open surgery, and study the advantage of 3D laparoscopic radical gastrectomy. Methods Clinical data of 450 patients with gastric cancer in our hospital from January 2013 to January 2018 were analyzed retrospectively including 126 cases in 3D laparoscopy group, 219 cases in 2D laparoscopy group and 105 cases in open surgery group. Surgical parameters, postoperative recovery and morbidity were compared among three groups combined with serum inflammatory factor before surgery and 3 days later. Results Less operative time and less operative blood loss were found in 3D laparoscopy group and 2D laparoscopy group comparing with those in open surgery group. Anal exhaust, ambulation and postoperative hospital stay in 3D laparoscopy group and 2D laparoscopy group were shorter than those in open surgery group (P<0.05). The intraoperative and postoperative parameters in 3D laparoscopy group were better than those in 2D laparoscopy group (P<0.05). There was no difference in the number of lymph node retrieved among three groups (P<0.05). Three days after operation, the levels of serum C-reactive protein (CRP), interleukin-6 and tumor necrosis factor-α in open surgery group were higher than those before operation (P<0.05). The levels of serum CRP in 3D and 2D laparoscopy group were higher than those before operation (P<0.05). The levels of serum inflammatory factors in 3D and 2D laparoscopy group were lower than those in open surgery group (P<0.05). There was lower morbidity in 3D and 2D laparoscopy group than in open surgery group (P<0.05). However, no significant difference in morbidity was present between 3D and 2D laparoscopy group (P>0.05). Conclusions The patients with gastric cancer undergoing laparoscopic radical gastrectomy had faster recovery, less morbidity and mild inflammatory reaction with the most advantage in 3D laparoscopy gastrectomy, the shortest operation time, the least blood loss, the fastest recovery.
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