Objective To investigate the effect and safety of enhanced recovery after surgery(ERAS) in liver transplantation for hepatocellular carcinoma. Methods A retrospective study was performed to compare the clinical results of periopertive ERAS of 24 patients with liver transplatation for hepatcelllualr carcinoma in ERAS group from June 2016 to December 2018 with those of 28 patients in control group without ERAS protocol from January 2014 to May 2016. Results There was less fluid volume intraoperatively in ERAS group compared to that in control group(P<0.05). Earlier remove drain and tube including intubation and nasogastric tube, arterial and deep venous catheters, urinary catheter and abdominal drain combined with earlier normal food intake were gotten in ERAS group compared with those in control group(P<0.05). There were earlier return to normal hepatic function and less stay in both ICU and hospital in ERAS group than in control group(P<0.05). However, no differences between two groups were observed in preoperative data, duration of donor cold ischemia, operative time, ahepatic phrase, no transfusion ratio, amount of blood loss and blood transfused, postoperative complications and mortality and 1-month readmission rates (P>0.05). Conclusions ERAS is feasible and safe in some patients with hepatocellular carcinoma during liver transplantation with less stay in both ICU and hospital.