Journal of Surgery Concepts & Practice >

2022 , Vol. 27 >Issue 02: 173 - 179

DOI: https://doi.org/10.16139/j.1007-9610.2022.02.017

Original article

A meta-analysis for efficacy of prophylactic antibiotics on tension-free hernia repair

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  • 1. First Clinical Medical College of Lanzhou University, Gansu Lanzhou 730030, China
    2. Department of General Surgery, First Affiliated Hospital of Lanzhou University, Gansu Lanzhou 730030, China

Received date: 2020-12-11

  Online published: 2022-06-16

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Abstract

Objective To perform a meta-analysis of randomized controlled trial (RCT) comparing prophylactic antibiotics with placebo in patients with tension-free hernia repair for clinical effectiveness. Methods RCTs were searched from electronic Chinese databases including: ①China Biology Medicine Disc, ②China National Knowledge Infrastructure, ③China Science and Technology Journal Database, and ④Vanfund Urban Investment & Development, as well as electronic foreign databases including: PubMed, Cochrane Library, and Embase. The Review manager software (version 5.3) was used for statistical analysis. Results A total of 10 RCTs with both prophylactic antibiotic group and placebo group involving 3 659 patients were included. It was shown in this meta-analysis that there was no significant difference in the incidence of postoperative superficial incisional surgical site infection (SSSI) in low-risk environments (RR=0.74, 95% CI: 0.45-1.24) or postoperative deep surgical site infection (DSSI) (RR=0.71, 95% CI: 0.23-2.21) between two groups. The results from 4 RCTs showed that incidence of postoperative SSSI in high-risk environments in prophylactic antibiotic group was lower than that in placebo group(RR=0.34, 95%CI: 0.12-0.95, P=0.04). Conclusions Prophylactic antibiotics before tension-free hernia repair may help to reduce the incidence of postoperative SSSI in high-risk environments, but there is no significant evidence for that in low-risk environments.

Key words： Inguinal hernia; Tension-free hernia repair; Antibiotic; Meta-analysis; Randomized controlled trial

Cite this article

JIANG Weirong, YU Yongjiang . A meta-analysis for efficacy of prophylactic antibiotics on tension-free hernia repair[J]. Journal of Surgery Concepts & Practice, 2022 , 27(02) : 173 -179 . DOI: 10.16139/j.1007-9610.2022.02.017

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