Objective To explore prognotic significance of plasma procalcitonin (PCT) and C?reactive protein (CRP) in evaluation of multiple trauma patients. Methods The clinical data of 331 multiple trauma patients were collected in Department of Emergency, the Third Affiliated Hospital of Soochow University from January 2016 to December 2019. Patients were divided into survival group at day 28 survived after admission and death group. Plasma PCT and CRP levels at admission associated with prognosis were compared between two groups. Results Of 331 patients with more males than females (247 vs. 84), 306 (92.4%) were in survival group and 25(7.6%) in death group. Systolic pressure, diastolic pressure, hemoglobin, and albumin levels were lower in death group than those in survival group(P<0.05). Heart rate, prothrombin time, D-dimers, alanine aminotransferase, aspartate aminotransferase, glucose, creatinine, creatine kinase, lactic acid, lactate dehydrogenase, CRP, and PCT in serum were all higher in death group than those in survival group (P<0.05). The difference in mortality was statistically significant among the patients grouping based on PCT or CRP levels (P<0.05). Trend test showed an upward trend of mortality of patients when PCT and CRP levels increased (P_trend<0.001). PCT level correla-ted positive with CRP indicated by correlation analysis(r=0.176, P=0.001). Receiver operating characteristic curve showed that prediction on risk of death in multiple trauma patients was greater when using PCT combined with CRP [area under curve (AUC)=0.874] than PCT (AUC=0.795) and CRP (AUC=0.733). Conclusions PCT and CRP levels would have good predictive power in the evaluation of severity and prognosis of multiple trauma patients and would be important in clinical practice.