Journal of Surgery Concepts & Practice >
Prognosis of invasive micropapillary carcinoma versus invasive ductal carcinoma of the breast: a comparative analysis after propensity score matching
Received date: 2021-03-01
Online published: 2022-08-02
Objective To investigate the difference in prognosis between invasive micropapillary carcinoma (IMPC) and invasive ductal carcinoma(IDC) of the breast and the factors influencing the prognosis of breast carcinoma using propensity score matching (PSM). Methods The retrospective study was performed enrolling the patients with IMPC or IDC in Shanghai Jiao Tong University Breast Cancer Database and the data of clinicopathological characteristics and treatments and follow-up from January 2011 to December 2017. The differences in clinicopathological characteristics and treatments between IMPC and IDC were analyzed. PSM was conducted to balance the confounding factors between IMPC group and IDC group. The difference in prognosis and the factors influencing prognosis of breast carcinoma between two groups after PSM were analyzed. Results A total of 111 cases in IMPC group and 2 865 cases in IDC group were studied. There were more cases in IMPC group who had the expression including estrogen receptor, progesterone receptor and human epidermal growth factor receptor 2, and lymph node metastasis, mastectomy and endocrine therapy when compared those with the cases in IDC group (P<0.05). The rate of breast cancer-free interval (BCFI) in IMPC group was significantly lower than that in IDC group (P=0.022). No significant difference was present in rate of overall survival (OS) between two groups (P=0.268). There were 109 pairs of patients after PSM. The significant difference was not found in clinicopathological characteristics and treatments (P>0.05), and in the rate of BCFI or the rate of OS (P>0.05) between IMPC group and IDC group. It was shown in multivariate analysis of clinicopathological characteristics and treatments that the index of more than 3 positive lymph nodes was an independent risk factor associated with BCFI. Conclusions The prognosis was similar between IMPC and IDC after PSM and the index of more than 3 positive lymph nodes could be an independent risk factor of prognosis.
CHEN Yuanyuan, YE Xin, TANG Yongzhe, WANG Jie, HE Qi . Prognosis of invasive micropapillary carcinoma versus invasive ductal carcinoma of the breast: a comparative analysis after propensity score matching[J]. Journal of Surgery Concepts & Practice, 2021 , 26(04) : 353 -360 . DOI: 10.16139/j.1007-9610.2021.04.014
| [1] | Li W, Han Y, Wang C, et al. Precise pathologic diagnosis and individualized treatment improve the outcomes of invasive micropapillary carcinoma of the breast: a 12-year prospective clinical study[J]. Mol Pathol, 2018, 31(6):956-964. |
| [2] | 《乳腺癌HER2检测指南》编写组. 乳腺癌HER2检测指南(2009版)[J]. 中华病理学杂志, 2009, 38(12):836-840. |
| [3] | 《乳腺癌HER2检测指南》编写组. 乳腺癌HER2检测指南(2014版)[J]. 中华病理学杂志, 2014, 43(4):262-267. |
| [4] | Goldhirsch A, Winer EP, Coates AS, et al. Personalizing the treatment of women with early breast cancer: highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2013[J]. Ann Oncol, 2013, 24(9):2206-2223. |
| [5] | 陈舒婕, 陈小松, 籍敏, 等. 含微乳头成分的乳腺浸润性黏液癌的分析[J]. 外科理论与实践, 2019, 24(5):440-445. |
| [6] | Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. Ca Cancer J Clin, 2021, 71(3):209-249. |
| [7] | Cserni G. Histological type and typing of breast carcinomas and the WHO classification changes over time[J]. Pathologica, 2020, 112(1):25-41. |
| [8] | Yang YL, Liu BB, Zhang X, et al. Invasive micropapillary carcinoma of the breast: an update[J]. Arch Pathol Lab Med, 2016, 140(8):799-805. |
| [9] | Ide Y, Horii R, Osako T, et al. Clinicopathological significance of invasive micropapillary carcinoma component in invasive breast carcinoma[J]. Pathol Int, 2011, 61(12):731-736. |
| [10] | 张燕娜, 王常珺, 周易冬, 等. 乳腺浸润性微乳头状癌与浸润性癌(非特殊型)腋窝淋巴结转移相关因素的病例对照研究[J]. 协和医学杂志, 2015, 6(3):166-172. |
| [11] | Gokce H, Durak MG, Akin MM, et al. Invasive micropapillary carcinoma of the breast: a clinicopathologic study of 103 cases of an unusual and highly aggressive variant of breast carcinoma[J]. Breast J, 2013, 19(4):374-381. |
| [12] | 华彬, 陆旭, 肖文政, 等. 乳腺浸润性微乳头状癌与浸润性导管癌预后比较的单中心回顾性病例配对研究[J]. 中华外科杂志, 2018, 56(1):56-60. |
| [13] | 付丽, 松山郁生, 付笑影, 等. 乳腺浸润性微乳头状癌的形态改变与生物学行为的关系[J]. 中华病理学杂志, 2004, 33(1):21-25. |
| [14] | Marchiò C, Iravani M, Natrajan R, et al. Mixed micropapillary-ductal carcinomas of the breast: a genomic and immunohistochemical analysis of morphologically distinct components[J]. J Pathol, 2009, 218(3):301-315. |
| [15] | Tang SL, Yang JQ, Du ZG, et al. Clinicopathologic study of invasive micropapillary carcinoma of the breast[J]. Oncotarget, 2017, 8(26):42455-42465. |
| [16] | Chen AC, Paulino AC, Schwartz MR, et al. Population-based comparison of prognostic factors in invasive micropapillary and invasive ductal carcinoma of the breast[J]. Br J Cancer, 2014, 111(3):619-622. |
| [17] | 郑霞, 刘冰冰, 孟凡凡, 等. 乳腺浸润性微乳头状癌组织β1 integrin及Rac1和RhoA表达研研究[J]. 中国肿瘤临床, 2017, 44(14):695-700. |
| [18] | Marchiò C, Iravani M, Natrajan R, et al. Genomic and immunophenotypical characterization of pure micropapillary carcinomas of the breast[J]. J Pathol, 2008, 215(4):398-410. |
| [19] | Yu JI, Choi DH, Huh SJ, et al. Differences in prognostic factors and failure patterns between invasive micropapillary carcinoma and carcinoma with micropapillary component versus invasive ductal carcinoma of the breast: retrospective multicenter case-control study (KROG 13-06)[J]. Clin Breast Cancer, 2015, 15(5):353-361. |
| [20] | Shi WB, Yang LJ, Hu X, et al. Clinico-pathological features and prognosis of invasive micropapillary carcinoma compared to invasive ductal carcinoma: a population-based study from China[J]. PloS One, 2014, 9(6):e101390. |
| [21] | Li G, Yang S, Yao J, et al. Invasive micropapillary carcinoma of the breast had poor clinical characteristics but showed no difference in prognosis compared with invasive ductal carcinoma[J]. World J Surg Oncol, 2016, 14(1):207. |
| [22] | Wu Y, Zhang N, Yang Q. The prognosis of invasive micropapillary carcinoma compared with invasive ductal carcinoma in the breast: a meta-analysis[J]. BMC Cancer, 2017, 17(1):839. |
| [23] | 吴楠, 李莹, 吴梓政, 等. 195例乳腺浸润性微乳头状癌临床病理及预后分析[J]. 中华普通外科杂志, 2017, 32(5):397-401. |
| [24] | Lenis D, Nguyen TQ, Dong N, et al. It's all about ba-lance: propensity score matching in the context of complex survey data[J]. Biostatistics, 2019, 20(1):147-163. |
| [25] | Hao S, Zhao YY, Peng JJ, et al. Invasive micropapillary carcinoma of the breast had no difference in prognosis compared with invasive ductal carcinoma: a propensity-matched analysis[J]. Sci Rep, 2019, 9(1):286-293. |
| [26] | Azambuja E, Cardoso F, Castro G, et al. Ki-67 as prognostic marker in early breast cancer: a meta-analysis of published studies involving 12,155 patients[J]. Br J Cancer, 2007, 96(10):1504-1513. |
| [27] | 张月严, 李强, 栗海涛, 等. Ki67表达比例对乳腺癌病人预后影响的Meta分析[J]. 现代肿瘤医学, 2019, 27(11):1890-1894. |
| [28] | 张世超, 陆苏, 赵紫薇, 等. 乳腺浸润性微乳头状癌的临床病理特征及预后分析[J]. 中国肿瘤临床, 2020, 47(2):77-81. |
| [29] | Ye F, Yu P, Li N, et al. Prognosis of invasive micropa-pillary carcinoma compared with invasive ductal carcinoma in breast: a meta-analysis of PSM studies[J]. Breast, 2020, 51:11-20. |
| [30] | Vingiani A, Maisonneuve P, Dell'orto P, et al. The clinical relevance of micropapillary carcinoma of the breast: a case-control study[J]. Histopathology, 2013, 63(2):217-224. |
| [31] | Lewis GD, Xing Y, Haque W, et al. Prognosis of lymphotropic invasive micropapillary breast carcinoma analyzed by using data from the National Cancer Database[J]. Cancer Commun, 2019, 39(1):60-68. |
/
| 〈 |
|
〉 |
