Objective To evaluate the clinical efficacy of endoscopic full thickness resection in treatment of small gastric submucosal tumors (diameter≤1 cm). Methods A total of 102 patients with small gastric submucosal tumors treated using endoscopic full thickness resection in Zhongshan Hospital, Fudan University between January 2015 and December 2015 were analyzed retrospectively. Tumor resection rate, procedure time, interoperative bleeding and postoperative complications were observed in the procedures. Patients had follow-up endoscopy for evaluation of efficacy and safety. Results Endoscopic treatment was successful and resection of tumor was complete for all 102 patients. The average procedure time was (34.8±7.5) (11-126) min, Tumor diameter was (0.50±0.36) (0.3-1.0) cm and located all at gastric fundus. Pathological diagnose showed that 51 cases were with stromal tumor(50%), 45 cases with leiomyoma(44.1%), 2 cases with fibroma (2.0%), 2 cases with neuroendocrine tumors(2.0%), 1 case with hamartoma(1.0%), and 1 case with lymphoma(1.0%). Bleeding and perforation were not found and lesion surface of stomach was repaired well shown by follow-up. Conclusions Endoscopic full thickness resection in treatment of gastric submucosal tumors is effective and safe.