Journal of Surgery Concepts & Practice >

2024 , Vol. 29 >Issue 01: 74 - 80

DOI: https://doi.org/10.16139/j.1007-9610.2024.01.12

Review

Advantages and advances in neoadjuvant therapy of pancreatic cancer

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  • Department of General Surgery, Pancreatic Disease Center, Ruijin Hospital, Research Institute of Pancreatic Diseases, Shanghai Key Laboratory of Translational Research of Pancreatic Tumors, Shanghai Jiao Tong University School of Medicine; State Key Laboratory of Oncogenes and Related Genes(Shanghai), China; Institute of Translational Medicine, Shanghai Jiao Tong University, Shanghai 200025, China

Received date: 2022-06-29

  Online published: 2024-05-14

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Abstract

Due to the characteristics of the insidious onset, difficult early diagnosis and high malignancy of pancrea-tic cancer, only a minority of patients still have the chance of surgical resection at the time of diagnosis. In recent years, chemotherapy-based preoperative neoadjuvant therapy has been increasingly applied to pancreatic cancer without distant metastases to help achieve tumor downstaging, increase R0 resection rate and improve patient survival. A large number of clinical trials have proven the advantages of neoadjuvant therapy for pancreatic cancer, but there are still many issues to be gradually addressed by further research to reach a consensus.

Key words： Pancreatic Cancer; Neoadjuvant chemotherapy; Neoadjuvant radiochemotherapy

Cite this article

HU Binwei, SHEN Baiyong . Advantages and advances in neoadjuvant therapy of pancreatic cancer[J]. Journal of Surgery Concepts & Practice, 2024 , 29(01) : 74 -80 . DOI: 10.16139/j.1007-9610.2024.01.12

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