Review

Research status and prospects of colorectal cancer vaccine

  • JIA Wenqing ,
  • ZHANG Tao ,
  • ZHAO Ren
Expand
  • Department of General Surgery, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China

Received date: 2024-06-11

  Online published: 2024-09-03

Abstract

Colorectal cancer(CRC) ranks in third place in terms of incidence but second in terms of mortality. Cancer vaccine, as a novel immunotherapy, presents tumor antigens to human immune system and further elicits anti-tumor immune response, leading to long-term immune memory. This review summarized representative research progress in both clinical and basic scenario of past five years, and prospected the future of CRC vaccine.

Cite this article

JIA Wenqing , ZHANG Tao , ZHAO Ren . Research status and prospects of colorectal cancer vaccine[J]. Journal of Surgery Concepts & Practice, 2024 , 29(03) : 264 -269 . DOI: 10.16139/j.1007-9610.2024.03.14

References

[1] BRAY F, LAVERSANNE M, SUNG H, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin, 2024, 74(3):229-263.
[2] ANDRé T, SHIU K K, KIM T W, et al. Pembrolizumab in microsatellite-instability-high advanced colorectal cancer[J]. N Engl J Med, 2020, 383(23):2207-2218.
[3] LENZ H J, VAN CUTSEM E, LUISA LIMON M, et al. First-line nivolumab plus low-dose ipilimumab for microsatellite instability-high/mismatch repair-deficient metastatic colorectal cancer: the phase Ⅱ checkmate 142 study[J]. J Clin Oncol, 2022, 40(2):161-170.
[4] CARLSEN L, HUNTINGTON K E, EL-DEIRY W S. Immunotherapy for colorectal cancer: mechanisms and predictive biomarkers[J]. Cancers(Basel), 2022, 14(4):1028.
[5] SAXENA M, VAN DER BURG S H, MELIEF C J M, et al. Therapeutic cancer vaccines[J]. Nat Rev Cancer, 2021, 21(6):360-378.
[6] SAHIN U, TüRECI ?. Personalized vaccines for cancer immunotherapy[J]. Science, 2018, 359(6382):1355-1360.
[7] JIA W, ZHANG T, HUANG H, et al. Colorectal cancer vaccines: the current scenario and future prospects[J]. Front Immunol, 2022, 13:942235.
[8] HUBBARD J M, T?KE E R, MORETTO R, et al. Safety and activity of PolyPEPI1018 combined with maintenance therapy in metastatic colorectal cancer: an open-label, multicenter, phase Ⅰb study[J]. Clin Cancer Res, 2022, 28(13):2818-2829.
[9] PASCOLUTTI R, YETURU L, PHILIPPIN G, et al. ATP128 clinical therapeutic cancer vaccine activates NF-κB and IRF3 pathways through TLR4 and TLR2 in human monocytes and dendritic cells[J]. Cancers(Basel), 2022, 14(20):5134.
[10] KOPETZ S, PRENEN H, SHARMA S, et al. SO-11 KISIMA-01 trial: safety, tolerability and immunogenicity of ATP128 with or without ezabenlimab (BI 754091) in patients with stage Ⅳ colorectal cancer - preliminary results from a phase Ⅰb study[J]. Ann Oncol, 2021, 32:S206-S207.
[11] ZHENG Y, FU Y, WANG P P, et al. Neoantigen: a pro-mising target for the immunotherapy of colorectal cancer[J]. Dis Markers, 2022, 2022:8270305.
[12] SAHIN U, DERHOVANESSIAN E, MILLER M, et al. Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer[J]. Nature, 2017, 547(7662):222-226.
[13] YU Y J, SHAN N, LI L Y, et al. Preliminary clinical study of personalized neoantigen vaccine therapy for microsatellite stability (MSS)-advanced colorectal cancer[J]. Cancer Immunol Immunother, 2023, 72(7):2045-2056.
[14] PANT S, WAINBERG Z A, WEEKES C D, et al. Lymph-node-targeted, mKRAS-specific amphiphile vaccine in pancreatic and colorectal cancer: the phase 1 AMPLIFY-201 trial[J]. Nat Med, 2024, 30(2):531-542.
[15] LIU C, SHI Q, HUANG X, et al. mRNA-based cancer therapeutics[J]. Nat Rev Cancer, 2023, 23(8):526-543.
[16] LOPEZ J S, CAMIDGE R, IAFOLLA M, et al. Abstract CT301: a phase Ⅰb study to evaluate RO7198457, an individualized Neoantigen Specific immunoTherapy (iNeST), in combination with atezolizumab in patients with locally advanced or metastatic solid tumors[J]. Cancer Res, 2020, 80(16_Supplement):CT301-CT301.
[17] PALMER C D, RAPPAPORT A R, DAVIS M J, et al. Individualized, heterologous chimpanzee adenovirus and self-amplifying mRNA neoantigen vaccine for advanced metastatic solid tumors: phase 1 trial interim results[J]. Nat Med, 2022, 28(8):1619-1629.
[18] CATENACCI D V, LIAO C Y, MARON S, et al. 960MO Clinical outcomes and immune responses in a phase Ⅰ/Ⅱ study of personalized, neoantigen-directed immunotherapy in patients with advanced MSS-CRC, GEA and NSCLC[J]. Ann Oncol, 2021, 32:S830-S831.
[19] GRISTONE BIOLOGY. Gritstone announces updated overall survival results from granite phase Ⅰ/Ⅱ study and poster at SITC 2022[EB/OL]. (2022-11-10)[2024-06-11]. https://ir.gritstonebio.com/news-releases/news-release-details/gritstone-announces-updated-overall-survival-results-granite.
[20] REN Y, MANOHARAN T, LIU B, et al. Circular RNA as a source of neoantigens for cancer vaccines[J]. J Immunother Cancer, 2024, 12(3):e008402.
[21] SMALL E J, SCHELLHAMMER P F, HIGANO C S, et al. Placebo-controlled phase Ⅲ trial of immunologic therapy with Sipuleucel-T (APC8015) in patients with metastatic, asymptomatic hormone refractory prostate cancer[J]. J Clin Oncol, 2006, 24(19):3089-3094.
[22] RODRIGUEZ J, CASTA?óN E, PEREZ-GRACIA J L, et al. A randomized phase Ⅱ clinical trial of dendritic cell vaccination following complete resection of colon cancer liver metastasis[J]. J Immunother Cancer, 2018, 6(1):96.
[23] ESPA?OL-REGO M, FERNáNDEZ-MARTOS C, ELEZ E, et al. A phase Ⅰ-Ⅱ multicenter trial with Avelumab plus autologous dendritic cell vaccine in pre-treated mismatch repair-proficient (MSS) metastatic colorectal cancer patients; GEMCAD 1602 study[J]. Cancer Immunol Immunother, 2023, 72(4):827-840.
[24] MARUOKA S, OJIMA T, IWAMOTO H, et al. Tumor RNA transfected DCs derived from iPS cells elicit cytotoxicity against cancer cells induced from colorectal cancer patients in vitro[J]. Sci Rep, 2022, 12(1):3295.
[25] HARRIS J E, RYAN L, HOOVER H C, et al. Adjuvant active specific immunotherapy for stage Ⅱ and Ⅲ colon cancer with an autologous tumor cell vaccine: eastern cooperative oncology group study E5283[J]. J Clin Oncol, 2000, 18(1):148-157.
[26] BAARS A, CLAESSEN A M E, WAGSTAFF J, et al. A phase Ⅱ study of active specific immunotherapy and5-FU/Leucovorin as adjuvant therapy for stage Ⅲ colon carcinoma[J]. Br J Cancer, 2002, 86(8):1230-1234.
[27] YARCHOAN M, HUANG C Y, ZHU Q, et al. A phase 2 study of GVAX colon vaccine with cyclophosphamide and pembrolizumab in patients with mismatch repair proficient advanced colorectal cancer[J]. Cancer Med, 2020, 9(4):1485-1494.
[28] JIA W, SHEN X, GUO Z, et al. The future of cancer vaccines against colorectal cancer[J]. Expert Opin Biol Ther, 2024, 24(4):269-284.
[29] LAROCCA C, SCHLOM J. Viral vector-based therapeutic cancer vaccines[J]. Cancer J, 2011, 17(5):359-371.
[30] MORSE M A, CHAUDHRY A, GABITZSCH E S, et al. Novel adenoviral vector induces T-cell responses despite anti-adenoviral neutralizing antibodies in colorectal cancer patients[J]. Cancer Immunol Immunother, 2013, 62(8):1293-1301.
[31] REDMAN J M, TSAI Y T, WEINBERG B A, et al. A randomized phase Ⅱ trial of mFOLFOX6 + Bevacizumab alone or with AdCEA vaccine + Avelumab immunotherapy for untreated metastatic colorectal cancer[J]. Oncologist, 2022, 27(3):198-209.
[32] OLADEJO M, PATERSON Y, WOOD L M. Clinical experience and recent advances in the development of Listeria-based tumor immunotherapies[J]. Front Immunol, 2021, 12:642316.
[33] YU Y, ZHANG J, NI L, et al. Neoantigen-reactive T cells exhibit effective anti-tumor activity against colorectal cancer[J]. Hum Vaccin Immunother, 2022, 18(1):1-11.
[34] CLEYLE J, HARDY M P, MINATI R, et al. Immunopeptidomic analyses of colorectal cancers with and without microsatellite instability[J]. Mol Cell Proteomics, 2022, 21(5):100228.
[35] PLEGUEZUELOS-MANZANO C, PUSCHHOF J, ROSENDAHL HUBER A, et al. Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli[J]. Nature, 2020, 580(7802):269-273.
[36] DEJEA C M, FATHI P, CRAIG J M, et al. Patients with familial adenomatous polyposis harbor colonic biofilms containing tumorigenic bacteria[J]. Science, 2018, 359(6375):592-597.
[37] HOLT R A. Oncomicrobial vaccines: the potential for a Fusobacterium nucleatum vaccine to improve colorectal cancer outcomes[J]. Cell Host Microbe, 2023, 31(1):141-145.
[38] PADMA S, PATRA R, SEN GUPTA P S, et al. Cell surface fibroblast activation protein-2 (fap2) of Fusobacterium nucleatum as a vaccine candidate for therapeutic intervention of human colorectal cancer: an immunoinformatics approach[J]. Vaccines(Basel), 2023, 11(3):525.
[39] PRIYAMVADA P, RAMAIAH S. Pan-genome and reverse vaccinology approaches to design multi-epitope vaccine against Epstein-Barr virus associated with colorectal cancer[J]. Immunol Res, 2023, 71(6):887-908.
[40] KHAN S, AZIZ S, WAQAS M, et al. Targeted vaccine development against bilophila wadsworthia to curb colon diseases: a multiepitope approach based on reverse vaccinology and computational analysis[J]. Int J Biol Macromol, 2023, 250:126002.
[41] MITCHELL M J, BILLINGSLEY M M, HALEY R M, et al. Engineering precision nanoparticles for drug deli-very[J]. Nat Rev Drug Discov, 2021, 20(2):101-124.
[42] BLOOM K, VAN DEN BERG F, ARBUTHNOT P. Self-amplifying RNA vaccines for infectious diseases[J]. Gene Ther, 2021, 28(3-4):117-129.
[43] SCHIMANSKI C C, KASPER S, HEGEWISCH-BECKER S, et al. Adjuvant MUC vaccination with te-cemotide after resection of colorectal liver metastases: a randomized, double-blind, placebo-controlled, multicenter AIO phase Ⅱ trial (LICC)[J]. Oncoimmunology, 2020, 9(1):1806680.
[44] MOEHLER M, FOLPRECHT G, HEINEMANN V, et al. Survival after secondary liver resection in metastatic colorectal cancer: comparing data of three prospective randomized European trials ( LICC, CELIM, FIRE ‐3)[J]. Int J Cancer, 2022, 150(8):1341-1349.
[45] HORNBUCKLE K, FRITZ C D L. What is lynch syndrome?[J]. JAMA, 2024, 332(2):178.
[46] BOLIVAR A M, DUZAGAC F, SINHA K M, et al. Advances in vaccine development for cancer prevention and treatment in lynch syndrome[J]. Mol Aspects Med, 2023, 93:101204.
[47] D’ALISE M, WILLIS J, LEONI G, et al. 1526 Nous-209 genetic vaccine encoding shared cancer neoantigens is safe and elicits robust immune response in healthy lynch syndrome carriers: interim results from phase Ⅰ cancer interception trial[J]. BMJ Publishing Group Ltd,2023,A1751-A1751.
[48] JACKSON K, SAMADDAR S, MARKIEWICZ M A, et al. Vaccination-based immunoprevention of colorectal tumors: a primer for the clinician[J]. J Clin Gastroenterol, 2023, 57(3):246-252.
Outlines

/