Journal of Surgery Concepts & Practice >

2025 , Vol. 30 >Issue 04: 351 - 357

DOI: https://doi.org/10.16139/j.1007-9610.2025.04.10

Review

Progression in circulating tumor DNA detection for minimal residual disease in patients with colorectal cancer liver metastasis

  • LI Yaqi ,
  • MO Shaobo ,
  • PENG Junjie
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  • Department of Colorectal Surgery, Division Ⅱ, Fudan University Shanghai Cancer Center

Received date: 2024-04-03

  Online published: 2025-10-23

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Abstract

As a non-invasive biomarker, circulating tumor DNA (ctDNA) can sensitively identify minimal residual disease (MRD), offering a novel approach for prognosis prediction and efficacy evaluation in patients with colorectal cancer liver metastasis (CRLM), thereby aiding in the formulation of personalized treatment strategies. This article summarized the progress in the application of ctDNA detection for MRD in CRLM and provided insights into its future directions.

Key words： Colorectal cancer liver metastasis(CRLM); Circulating tumor DNA(ctDNA); Minimal residual disease(MRD); Prognostic prediction; Efficacy evaluation

Cite this article

LI Yaqi , MO Shaobo , PENG Junjie . Progression in circulating tumor DNA detection for minimal residual disease in patients with colorectal cancer liver metastasis[J]. Journal of Surgery Concepts & Practice, 2025 , 30(04) : 351 -357 . DOI: 10.16139/j.1007-9610.2025.04.10

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