组织工程与重建外科杂志 ›› 2009, Vol. 5 ›› Issue (3): 150-152.doi: 10.3969/j.issn.1673-0364.2009.06.009

• 论著 • 上一篇    下一篇

兔面神经外伤性损伤后恢复的实验研究

沈晨,郭智霖,欧阳火牛   

  1. 上海交通大学医学院附属第九人民医院神经外科;
  • 发布日期:2020-07-23

Experimental Study on Compression Facial Nerve Injury in Rabbits

SHEN Chen,GUO Zhilin,OUYANG Huoniu   

  1. Department of Neurology Surgery;The Ninth People s Hospital;Shanghai Jiaotong University School of Medicine;Shanghai 200011;China.;
  • Published:2020-07-23

摘要: 目的通过比较兔压榨性损伤组与正常组的面神经功能与组织学差异,研究面神经的损伤及其修复过程,为临床治疗周围性面瘫寻找合适的干预时机。方法15只普通级成年新西兰兔,分别对其左侧颞外面神经主干施以压榨性损伤,分别于损伤后2周、4周、6周取材,通过电生理测定、显微结构观测及相应的组织学量化分析等方法,比较实验组与对照组间的差异。结果损伤后2周时,大部分轴突颗粒状变性,髓鞘松解;4周时,部分轴突恢复正常;6周后,压迫组基本恢复正常结构,其电生理功能与形态学相符。损伤4周后,总体轴突密度为68.88%;6周后,总体轴突密度恢复至88.63%,与正常组比较均有统计学差异。结论兔面神经损伤2周后部分神经功能开始恢复,至6周时功能基本恢复。

关键词: 家兔, 损伤, 面神经, 功能, 修复

Abstract: Objective To study posttraumatic regeneration of the facial nerve in rabbits.Functional and histological analysis were compared with normal nerves on opposite sides to finding the suitable opportunity to treat the peripheral facial paralysis on clinic.Methods The left facial nerve trunks of 15 rabbits were selected to compression lesion and the right sides of them serve as the control groups.The rabbits were killed at 2,4 and 6 weeks after the operation,respectively.The obtained specimens were observed macr...

Key words: Rabbits, Injury, Facial nerve, Function, Regeneration

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