组织工程与重建外科杂志

组织工程与重建外科杂志 ›› 2012, Vol. 8 ›› Issue (4): 208-212.doi: 10.3969/j.issn.1673-0364.2012.04.007

• 论著 • 上一篇    下一篇

0.5%噻吗洛尔溶液局部治疗婴幼儿血管瘤的疗效观察

王俞明，耿峰，查宗煜，成戎，张正勇，苏薇洁，章一新   

  1. 芜湖市第二人民医院整形外科；芜湖市第二人民医院超声科；芜湖市第二人民医院皮肤科；芜湖市第一人民医院皮肤科；上海交通大学医学院附属第九人民医院整复外科
  • 发布日期:2020-07-23

Effectiveness of 0.5% Solution of Topical Timolol Maleate for Infantile Hemangiomas

WANG Yuming1,GENG Feng2,ZHA Zongyu2,CHENG Rong3,ZHANG Zhengyong4,SU Weijie5,ZHANG Yixin5   

  1. 1 Department of Plastic Surgery,Wuhu Second People’s Hospital,Anhui 241000,China;2 Department of Ultrasound,Wuhu Second People’s Hospital,Anhui 241000,China;3 Department of Dermatology,Wuhu Second People’s Hospital,Anhui 241000,China;4 Department of Dermatology,Wuhu First People’s Hospital,Anhui 241000,China;5 Department of Plastic and Reconstructive Surgery,Shanghai Ninth People’s Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 200011,China.
  • Published:2020-07-23

摘要： 目的评价0.5%噻吗洛尔溶液局部治疗婴幼儿血管瘤的临床疗效和安全性。方法25例婴幼儿血管瘤患儿给予0.5%马来酸噻吗洛尔溶液血管瘤表面外用(30μL/cm2);对照组共17例婴幼儿血管瘤患儿给予生理盐水血管瘤表面外用(30μL/cm2)。每8 h使用1次,1天3次。每个月定期门诊复查,持续6个月,定期观察和记录血管瘤大小、质地、颜色变化,若出现严重症状和体征者及时给予对症治疗。结果治疗组疗效评定:优1例,好4例,中11例,差9例,总有效率64.00%;对照组疗效判定:优0例,好0例,中3例,差14例,总有效率17.65%。两组差异显著(P<0.05)。治疗组无明显不良反应。结论0.5%噻吗洛尔溶液局部治疗浅表型婴幼儿血管瘤疗效明显,不良反应少,患儿耐受性好。

关键词: 局部, 噻吗洛尔, 婴幼儿血管瘤

Abstract: Objective To investigate the clinical efficacy and safety of 0.5% solution of topical timolol maleate for infantile hemangiomas.Methods A total of 25 infants with hemangiomas were treated by 0.5% solution of timolol maleate topically every eight hours in a thin layer(30 μL/cm2) as treatment group,while 17 cases of infants with hemangiomas were treated with normal saline topically every eight hours in a thin layer(30 μL/cm2) as control group.The parents are responsible for topical application of drug every day.The treatment lasted for six months and the patients were visited once a month.The changes of tumor size,texture and color were monitored and recorded at a regular interval.Symptomatic treatment was given timely for any acute signs and symptoms.Results In treatment group,the overall response of excellent was evaluated in 1 patient,good in 4 patients,moderate in 11 patients,poor in 9 patients,and the total effective rate was 64.00%.In control group,the overall response of excellent was evaluated in 0 patient,good in 0 patient,moderate in 3 patients,poor in 14 patients,and the effective rate was 17.65%.There was significant difference between the two groups(P<0.05).No obvious adverse reactions were observed.Conclusion Topical timolol maleate shows good therapeutic effect for superficial hemangiomas with good drug tolerability and minor adverse reaction.

Key words: Topical, Timolol maleate, Infantile hemangiomas

中图分类号: