组织工程与重建外科杂志

组织工程与重建外科杂志 ›› 2013, Vol. 9 ›› Issue (5): 295-297.doi: 10.3969/j.issn.1673-0364.2013.05.016

• 论著 • 上一篇    

骨髓间充质干细胞治疗椎间盘退行性病变的研究进展

袁超群，张海龙   

  1. 同济大学附属上海第十人民医院骨科脊柱与微创中心
  • 发布日期:2020-07-23

Research Progress of Bone Marrow Mesenchymal Stem Cells in Degenerated Intervertebral Disc

YUAN Chaoqun,ZHANG Hailong   

  1. Department of Orthopaedics, Shanghai Tenth People’s Hospital, Tongji University School of Medicine
  • Published:2020-07-23
  • Contact: 上海市科学技术委员会科研计划项目（114119a2500）

摘要： 对椎间盘退变机制、BMSCs生物学特性、支架材料及细胞因子认识的深入,为BMSCs修复退变的椎间盘组织奠定了基础。研究表明,BMSCs治疗椎间盘退行性病变具有可行性,临床应用前景广阔。本文就BMSCs治疗椎间盘退行性病变的研究进展进行综述。

关键词: 组织工程, 骨髓间充质干细胞, 椎间盘, 退行性改变

Abstract: The further understanding of cellular scaffolds, cell factors, intervertebral disc (IVD) cell pathophysiology and BMSCs biology have laid the foundation of cell-based therapies for IVD degeneration. Moreover, a series of animal studies and vitro experiments also confirm the feasibility and effectiveness of cell-based therapies for IVD degeneration. It shows a wide prospect of clinical application in the future. The current research status of BMSCs in IVD tissue engineering was reviewed.

Key words: Tissue engineering, Bone marrow mesenchymal stem cells, Intervertebral disc, Degeneration

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