组织工程与重建外科杂志

组织工程与重建外科杂志 ›› 2017, Vol. 13 ›› Issue (1): 45-47.doi: 10.3969/j.issn.1673-0364.2017.01.013

• 综述 • 上一篇    下一篇

轴突信号Neuregulin 1 在施旺细胞发育及再生修复中的作用

郑亚妮，张志英   

  1. 第二军医大学解剖教研室、 再生医学中心
  • 发布日期:2020-07-23

The Effect of Axonal Signal Neuregulin 1 on the Development and Regeneration of Schwann Cells

ZHENG Yani   

  • Published:2020-07-23
  • Contact: 国家自然科学基金

摘要： 神经元轴突与施旺细胞(Schwann cells,SC)的相互接触和信号交流,在周围神经发育早期及其损伤后的修复、再生过程中,均具有极其重要的作用。在发育早期,神经元轴突对SC的增殖、迁移、分化和髓鞘化起着决定性作用。神经损伤后,沃勒变性使轴突与远侧SC失去接触,SC基因及表型发生改变,细胞增殖,促进轴突再生;当再生轴突与失神经SC形成接触则触动其第二次增殖。研究显示,神经元轴突通过Neuregulin 1(NRG1)及其erb B受体介导,提高SC的增殖活力,应用外源性NRG1能够挽救轴突损伤后的SC凋亡,使SC增殖、迁移,促进轴突再生。本文就NRG1对SCs增殖、分化、迁移、髓鞘化和损伤后的逆分化、再髓鞘化调控进行综述。

关键词: Neuregulin 1, 施旺细胞, 发育, 再生

Abstract: Physiological interactions and reciprocal signaling between axons and Schwann Cells (SC) play important roles in nerve development and regeneration after peripheral nerve injury. During development, axonal signaling is essential for SC proliferation, migration, differentiation and myelination. After nerve injury, Wallerian degeneration completely disrupts axon-SC contacts, SC genetic and phenotypic changes, cell proliferate and promote axon regeneration. When the regenerated axon contacts with denervated SC, the second proliferation wave begins. Studies have shown that neuronal axons through Neuregulin 1 (NRG1) and its erbB receptor to mediate the SCs proliferation activity, application of exogenous NRG1 can save SC and prevent apoptosis, promote SC proliferation and migration and axon regeneration. In this paper, NRG1 as a driving force for SC proliferation, differentiation, migration, myelination during development and redifferentiation, remyelination after injury were reviewed.

Key words: Neuregulin 1, Schwann cell, Development, Regeneration

中图分类号: