组织工程与重建外科杂志

组织工程与重建外科杂志 ›› 2017, Vol. 13 ›› Issue (6): 340-342.doi: 10.3969/j.issn.1673-0364.2017.06.011

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人尿源性干细胞在口腔组织工程中的应用及研究进展

章茜茹，陈林，王帅   

  1. 贵州省高等学校口腔疾病研究特色重点实验室，遵义医学院附属口腔医院
  • 收稿日期:2017-10-06 发布日期:2020-07-23

The Research Progress and Application of Human Urine Derived Stem Cells in Oral Tissue Engineering

ZHANG Qianru   

  • Received:2017-10-06 Published:2020-07-23
  • Contact: 贵州省科技厅科学技术基金计划；遵义医学院博士科研启动基金

摘要： 人尿源性干细胞(Human urine derived stem cells,h USC)作为一种新的干细胞来源,具有旺盛的增殖能力、高度自我更新能力、良好的多向分化潜能和旁分泌能力,取材无创且无免疫和伦理问题。作为一种理想的干细胞来源,人尿源性干细胞在组织工程和再生医学领域已经展示了广阔的应用前景,在泌尿系统疾病、骨组织工程等方面的相关研究,也揭示了h USC在口腔组织工程中具有应用潜能。本文就尿源干细胞的最新研究成果,及其在口腔组织工程中的应用和研究进展进行综述。

关键词: 人尿源性干细胞, 口腔组织工程, 细胞治疗, 类器官

Abstract: Human urine-derived stem cells (hUSC) have been reported, and regarded as a candidate for seed cells in tissue engineering, which are highly expandable, and have self-renewal capacity, multi-differentiation potential and paracrine properties. More importantly, hUSC can be obtained via a non-invasive, simple way, and are low immunogenic without medical ethics restrictions. hUSC as an ideal source of stem cells, have demonstrated a prosperous progress in scientific research and potential application in the field of tissue engineering and regenerative medicine. The research achievement in urinary system, bone tissue engineering also implies potential applications of hUSC in oral maxillofacial tissue regeneration. In this paper, the application of hUSC in oral tissue engineering and regeneration were reviewed by summarizing domestic and overseas research progress on hUSC.

Key words: Human urine derived stem cells, Oral tissue engineering, Cell therapy, Organoids

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