组织工程与重建外科杂志

组织工程与重建外科杂志 ›› 2017, Vol. 13 ›› Issue (6): 354-356.doi: 10.3969/j.issn.1673-0364.2017.06.015

• 综述 • 上一篇    下一篇

皮肤γδT细胞在维持上皮完整和伤口愈合中的作用

王配合，何泽亮，李晓东，安亮恩，卓勤强，刘玲玲   

  1. 中国人民解放军白求恩国际和平医院烧伤整形科
  • 收稿日期:2017-09-21 发布日期:2020-07-23

Skin γδT-Cell Functions in Epithelium Integrity and Wound Healing

WANG Peihe,HE Zeliang,LI Xiaodong,AN Liang'en,ZHUO Qinqiang,LIU Lingling   

  • Received:2017-09-21 Published:2020-07-23

摘要： 研究证实小鼠皮肤树突状表皮γδT细胞(Dendritic epidermalγδT cells,DETCs)表达的γδTCR,由Vγ3Jγ1-Cγ1和Vδ1Dδ2Jδ2-Cδ链组成,特异性表达于成年小鼠皮肤中。DETCs活化后分泌多种细胞因子、生长因子、趋化因子等,这些因子与组织修复,以及细胞存活、增殖、迁移和募集有关,在维持上皮组织完整性和上皮组织修复中发挥关键作用。本文就DETCs在维持上皮组织的完整和组织修复过程中的作用进行综述。

关键词: γδT细胞, 上皮完整, 组织修复, 皮肤

Abstract: The research showed that the dendritic epidermal γδ T cells (DETCs) found in murine skin expressed aγδTCR composed of Vγ3Jγ1-Cγ1and Vδ1Dδ2Jδ2-Cδ chains which specifically expressed in murine skin. Activated DETCs produce several cytokines, growth factors and chemokines. All these factors were related to tissue repair, cell survival, proliferation, migration, recruitment, and play a key role in maintaining the epithelium integrity and repairing the epithelial tissue. In this paper, the functions of DETCs in maintaining the epithelium integrity and would repair were reviewed.

Key words: γδT cell, Epithelium integrity, Tissue repair, Skin

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