组织工程与重建外科杂志

组织工程与重建外科杂志 ›› 2022, Vol. 18 ›› Issue (6): 485-.

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九一丹外用对难治性非哺乳期乳腺炎术后创腔修复的疗效研究

  

  • 出版日期:2022-12-01 发布日期:2023-01-12

Study on the effect of external application of Jiuyi Dan on the wound

cavity repair after operation of refractory non-puerperal mastitis

  • Online:2022-12-01 Published:2023-01-12

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摘要： 目的　探索九一丹对难治性非哺乳期乳腺炎（Refractory non-puerperal mastitis，RNPM）术后创面修复的疗效及安全性。方法　2020年12月至2021年12月，对切开扩创手术的RNPM患者，按术后干预方法不同分为观察组与对照组，对照组给予常规换药，观察组在对照组基础上外用中药制剂九一丹，分析两组不同干预措施对RNPM患者术后创腔的修复效果及安全性。结果　共78例患者，观察组38例、对照组40例。术后1周、3周，两组创腔体积无显著差异（P＞0.05）；术后3周与术后1周相比，观察组与对照组创腔体积分别缩小（23.59±14.19） mL、（16.96±10.78） mL，差异有统计学意义（t=2.06，P<0.05）；观察组术后创腔体积减少更为明显（F=4.22，P=0.04，偏η2=0.07）。观察组与对照组创口愈合时间≤2个月者分别占68.42%（26/38）和40%（16/40），创口愈合时间＞2个月者分别占31.58%（12/38）、60%（24/40），差异有统计学意义（χ2=6.33，P=0.01）。观察组术后6个月乳腺外形评分为（4.55±2.31）分，高于对照组的（3.38±1.98）分，差异有统计学意义（t=2.17，P=0.03）。两组治疗前后肝、肾功能指标无统计学差异（P>0.05）。结论　九一丹外用能有效促进难治性非哺乳期乳腺炎术后创腔组织的修复，保护乳腺外形，具有一定安全性。

关键词: 难治性非哺乳期乳腺炎, 　九一丹, 　中医疗法, 　创面愈合

Abstract: Objective　To explore the clinical effect and safety of Jiuyi Dan on the wound repair of refractory non-puerperal mastitis (RNPM). Methods　Patients with RNPM who were treated with incision and debridement from December 2020 to December 2021 were divided into observation group and control group according to the postoperative treatment method. The control group was given routine dressing change, and the observation group was given the traditional Chinese medicine preparation Jiuyi Dan for external use on the basis of the control group. The effect and safety of the two groups on the postoperative wound cavity repair of patients with RNPM were retrospectively analyzed. Results　A total of 78 patients were included, including 38 cases in the observation group and 40 cases in the control group. There was no significant difference in wound volume between the two groups at 1 and 3 weeks after operation (P>0.05). Compared with 1 week after operation, the volume reduction of wound cavity at 3 weeks after operation was (23.59±14.19) mL and (16.96±10.78) mL in the observation group and the control group, respectively, and the difference between the two groups was statistically significant (t=2.06, P<0.05). The volume of wound cavity decreased more significantly in the observation group (F=4.22, P=0.04, partial η2=0.07). The wound healing time ≤2 months accounted for 68.42% (26/38) and 40% (16/40) in the observation group and the control group, respectively, and the wound healing time >2 months accounted for 31.58%(12/38) and 60%(24/ 40) in the observation group and the control group, respectively, with a statistically significant difference (χ2=6.33, P=0.01). The score of breast shape 6 months after operation in the observation group was 4.55±2.31, which was higher than that in the control group (3.38±1.98), and the difference between the two groups was statistically significant (t=2.17, P=0.03). There was no significant difference in liver and kidney function between the two groups before and after treatment(P>0.05). Conclusion　The external application of Jiuyi Dan can effectively promote the repair of wound cavity tissue after operation of RNPM, protect the appearance of breast, and has a certain safety.

Key words: Refractory non-puerperal mastitis, 　Jiuyi Dan, 　Traditional Chinese medicine therapy, 　Wound healing