组织工程与重建外科杂志 ›› 2023, Vol. 19 ›› Issue (1): 22-.

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“核心剥离式”瘢痕疙瘩修薄术联合放疗的疗效分析

  

  • 出版日期:2023-02-01 发布日期:2023-03-08

 Efficacy analysis of‘core stripping’keloid thinning surgery combined with radiotherapy

  • Online:2023-02-01 Published:2023-03-08

摘要:

目的 探究“核心剥离式”瘢痕疙瘩修薄术联合放疗对于瘢痕疙瘩治疗的效果。方法 采取回顾性研究以及自身前后对照,选取 2020 年 1 月—2020 年 12 月收治的 43 例边缘呈坡形的瘢痕疙瘩患者,共 326 处瘢痕疙瘩病灶,行“核心剥离式”瘢痕疙瘩修薄术,在保留约 1 mm 厚度瘢痕皮片情况下剥离并切除瘢痕核心组织,保留真皮网状层,以“改良褥式缝合法”缝合固定瘢痕皮片。术后采用 6 MeV 电子线放射治疗 2 次,第 1 次放疗于术后 24 h 内完成,7 d 后进行第 2 次放疗,单次照射剂量为 9 Gy。治疗结束后 6 个月、12 个月及18 个月时随访。采用患者与观察者瘢痕评估量表(The patient and observer scar scale,POSAS)分析治疗结果,统计治疗有效率及治疗后 18 个月患者满意度。

结果 治疗后 POSAS 总分、患者总分、观察者总分均较治疗前显著降低。部分患者出现不同程度的色素沉着、脱失,局部毛发脱落,及短暂的皮炎、神经炎表现,后均自行改善。治疗结束后 18 个月的总复发率为 30.23%。43 例瘢痕疙瘩中,17 例(39.53%)患者对疗效非常满意,22 例(51.62%)患者对疗效满意,4 例(9.3%)患者对疗效不满意,总体满意率为 90.7%。结论 “核心剥离式”瘢痕疙瘩修薄术是一种快速有效的瘢痕疙瘩减容手术,配合术后放疗具有良好的治疗效果。

关键词:

Abstract:

Objective To explore the effect of "core stripping" keloid thinning surgery combined with radiotherapy in the
treatment of keloid. Methods From January 2020 to December 2020, 43 patients with slope keloid and 326 keloid lesions
were selected by retrospective study and self-control. The "core stripping" keloid thinning surgery was used to separate and
remove the core tissue of keloid while retaining the scar skin with a thickness of about 1 mm. The reticular dermis was retained,
and the scar skin was sutured and fixed by the "modified mattress suture method". After surgery, 6 Mev electron radiotherapy
was performed twice. The first radiotherapy was completed within 24 hours after operation, and the second radiotherapy was
performed 7 days later. The single dose of radiotherapy was 9 Gy. Follow-up was performed at 6 months, 12 months and 18
months after the end of treatment. The patient and observer scar scale (POSAS) was used to analyze the treatment outcomes, and 
the treatment response rate and patients' satisfaction at 18 months after treatment were statistically analyzed. Results The total
score of POSAS, total score of patients, and total score of observers were significantly lower after treatment than before treatment.
Some patients had different degrees of hyperpigmentation, hypopigmentation, local hair loss, transient dermatitis and neuritis,
which improved spontaneously. The total recurrence rate at 18 months after treatment was 30.23%. Among 43 keloid patients, 17
patients (39.53%) were very satisfied with the treatment outcome, 22 patients (51.62%) were satisfied, and 4 patients (9.3%) were
not satisfied. The overall satisfaction rate was 90.7%. Conclusion The "core stripping" keloid thinning surgery is a rapid and
effective keloid volume reduction surgery, which has a good therapeutic effect when combined with postoperative radiotherapy.

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