皮肤衰老相关的生物标志物及其作用机制的研究进展

摘要：

皮肤老化是人体衰老的直接表现，是遗传和环境因素共同作用的结果，表现为皮肤结构、功能和外观的累

积性变化，如皱纹增多、松弛、弹性减退、毛细血管扩张、皮肤色素异常等，延缓皮肤老化对维护人们的心理健康

和皮肤的正常生理功能具有重要意义。皮肤老化是一个高度复杂且尚未完全明了的过程，目前还无法根据单一的生

物标志物明确检测和评估衰老。本文对衰老相关的生物标志物及其作用机制进行了详细阐述。

关键词:

皮肤 , 　衰老 , 　生物标志物 , 　作用机制

Abstract:

　Skin aging is a direct manifestation of human aging, which is the result of the joint action of genetic and

environmental factors, and is manifested by cumulative changes in skin structure, function and appearance, such as increased

wrinkles, laxity, elastosis, telangiectasia, and skin pigmentation abnormalities, etc. It is of great significance to delay skin aging

in order to safeguard people’s mental health and the normal physiological function of the skin. Skin aging is a highly complex

and not yet fully understood process, and it is not yet possible to definitively detect and assess aging based on a single biomarker.

In this paper, aging-related biomarkers and their mechanisms of action were described in detail.

Key words:

Skin, 　Aging, 　Biomarkers, 　Mechanism

王珏, 王佳琦, 陈珩, 等.

皮肤衰老相关的生物标志物及其作用机制的研究进展

[J]. 组织工程与重建外科杂志, 2023, 19(6): 586-.

WANG Jue, WANG Jiaqi, CHEN Heng, et al.

Progress of skin aging-related biomarkers and their mechanisms [J]. Journal of Tissue Engineering and Reconstructive Surgery, 2023, 19(6): 586-.

[1]	魏思明, 姚文德, 王钠, 等. 皮肤软组织扩张术治疗先天性巨痣的应用及相关问题探讨 … [J]. 组织工程与重建外科杂志, 2023, 19(5): 450-.
[2]	…赵琛玉, 李崇崇, 孙雪, 等. 医疗美容类面部注射填充材料评价 [J]. 组织工程与重建外科杂志, 2023, 19(5): 517-.
[3]	轩辕欣阳, 徐佳珵, 王梦婷, 等. 基于单细胞转录组测序结果分析成纤维细胞促进口腔黏膜无瘢痕愈合的机制 [J]. 组织工程与重建外科杂志, 2023, 19(2): 115-.
[4]	韦坤辰, 谢芸, 李青峰. 皮肤软组织扩张的相关研究进展 [J]. 组织工程与重建外科杂志, 2023, 19(1): 70-.
[5]	杨雅骊, 黄林婷, 陈军, 等. 论课程思政背景下皮肤病学的教学设计和探索 [J]. 组织工程与重建外科杂志, 2023, 19(1): 97-.
[6]	余力. 腹壁整形[J]. 组织工程与重建外科杂志, 2007, 3(4): 181-185.

PDF (PC)