基于抗生素骨水泥的糖尿病足溃疡治疗策略研究进展

组织工程与重建外科杂志 ›› 2023, Vol. 19 ›› Issue (6): 591-.

基于抗生素骨水泥的糖尿病足溃疡治疗策略研究进展

发布日期:2024-01-03

Research progress on the treatment strategy of diabetic foot ulcers based on antibiotic bone cement

Published:2024-01-03

摘要/Abstract

摘要：

　糖尿病足溃疡（Diabetic foot ulceration，DFU）是糖尿病常见并发症，也是导致患者病情恶化、截肢甚至死

亡的重要原因。彻底清创、控制感染、重建血运和及时修复创面是 DFU 的治疗重点。目前抗生素骨水泥已被用于治

疗 DFU 创面，并且取得了满意的效果。本文通过分析总结现有的文献，发现抗生素骨水泥用于 DFU 中的常用策略为：

一期彻底清创后用抗生素骨水泥覆盖创面以控制感染，促进诱导膜生成；二期采用植皮、皮瓣移植、Ilizarov 技术等

修复创面。此外，本文列举相关抗生素骨水泥材料与多种辅助治疗技术的联合治疗，为临床治疗提供多种选择参考。

关键词:

糖尿病足溃疡 , 　抗生素骨水泥 , 　清创术 , 　感染

Abstract:

　Diabetic foot ulceration (DFU) is a common complication in diabetic patients and an important cause of

deterioration, amputation and even death. Thorough debridement, infection control, re-establishment of blood flow and timely

repair of the wound are the mainstays of treatment for DFU. Antibiotic bone cement has been used to treat DFU wounds with

satisfactory results. In this paper, the available literature was analyzed and found that the common strategy for the use of

antibiotic bone cement in DFU is to cover the wound with antibiotic bone cement to control infection and promote induction

membrane production after complete debridement in phase 1, and to repair the wound with skin grafting, flap grafting and Ilizarov

technique in phase 2. In addition, the relevant adjuvant treatments were listed based on antibiotic bone cement materials to

provide a variety of options for clinical treatment.

Key words:

　Diabetic foot ulcer, 　Antibiotic bone cement, 　Debridement, 　Infection

刘陈肖笑, 简扬, 张演基, 等.

基于抗生素骨水泥的糖尿病足溃疡治疗策略研究进展

[J]. 组织工程与重建外科杂志, 2023, 19(6): 591-.

LIU Chenxiaoxiao, JAN Yang, ZHANG Yanji, et al.

Research progress on the treatment strategy of diabetic foot ulcers based on antibiotic bone cement [J]. Journal of Tissue Engineering and Reconstructive Surgery, 2023, 19(6): 591-.