生物材料的灭菌

组织工程与重建外科杂志 ›› 2024, Vol. 20 ›› Issue (3): 354-.

生物材料的灭菌

出版日期:2024-06-01 发布日期:2024-07-05

Sterilization methods for biomaterials in biomedical applications

Online:2024-06-01 Published:2024-07-05

摘要/Abstract

摘要：

从第一代的惰性材料到第三代的活性材料，生物材料近年来发展迅速，在生物医学中展现出巨大的应用前景，但其有效的灭菌变得越来越困难；而生物材料有效的灭菌和消毒是其临床转化必不可少的重要步骤。本综述总结了针对生物材料的经典和新型的多种灭菌消毒方法，以及这些灭菌技术对生物材料理化性质的影响，同时讨论了各种方法的杀菌效果、毒性和实际应用中存在的问题，以期为生物材料研究中的灭菌方法选择提供参考。

关键词:

生物材料, 　水凝胶, 　脱细胞基质材料, 　灭菌

Abstract:

From the first generation of inert materials to the third generation of active materials， biomaterials have

developed rapidly in recent years， showing great application prospects in biomedicine， but its effective sterilization has

become increasingly difficult. Effective sterilization and disinfection of biomaterials are essential to achieve clinical

transformation. This review summarized the classical and emerging sterilization methods for biomaterials and the impact of

these sterilization technologies on the physicochemical properties of biomaterials. This review also discussed the sterilization

effect， toxicity， and problems in the practical application of various methods， intending to provide a reference for the

selection of sterilization methods in the research of biomaterials.

Key words:

Biomaterials, Hydrogel, Decellularized extracellular matrix, Sterilization

吴柯, 张郭, 周牧冉, 等.

生物材料的灭菌 [J]. 组织工程与重建外科杂志, 2024, 20(3): 354-.

WU Ke, ZHANG Guo, ZHOU Muran, et al. Sterilization methods for biomaterials in biomedical applications[J]. Journal of Tissue Engineering and Reconstructive Surgery, 2024, 20(3): 354-.

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[2]	杜林陆雯丽刘庆芬顾芬. 新型甘油／明胶基水凝胶在创面修复中的应用效果研究[J]. 组织工程与重建外科杂志, 2021, 17(4): 304-.