组织工程与重建外科杂志

组织工程与重建外科杂志 ›› 2014, Vol. 10 ›› Issue (6): 351-354.doi: 10.3969/j.issn.1673-0364.2014.06.014

• 综述 • 上一篇    下一篇

脂肪源性干细胞向心肌细胞诱导分化的研究进展

石园园，杨向群   

  1. 第二军医大学学员旅学员二队；第二军医大学解剖学教研室、再生医学研究中心
  • 发布日期:2020-07-23

Differentiation of Adipose-derived Stem Cells into Cardiomyocytes

SHI Yuanyuan,YANG Xiangqun   

  1. Company 2 of Clinical Medicine, Second Military Medical University; Department of Human Anatomy,Research Center of Regenerative Medicine, Second Military Medical University;
  • Published:2020-07-23
  • Contact: 国家自然科学基金(31170934)

摘要： 脂肪源性干细胞因具有生物学特性稳定、来源广泛、取材方便、数量充足、易于培养扩增的优点,且在特定的诱导条件下可以分化为心肌细胞,有望成为细胞治疗的理想来源。诱导方法的选择,影响分化因素的研究已成为了细胞治疗领域研究的热点。本文就脂肪源性干细胞向心肌细胞诱导分化的方法和机制的研究进展进行综述。

关键词: 脂肪源性干细胞, 诱导, 心肌细胞, 分化

Abstract: The use of stem cells in the treatment of myocardial infarct has been strongly pursued in recent years. Due to their availability, feasibility, plasticity, and their potential to differentiate into cardiomyocytes at specific media, adipose-derived stem cells （ASCs） have become an ideal source of donor cells. A significant effort has gone into elucidating which factors and techniques influence this differentiation. The methods and mechanisms of differentiation of ASCs into cardiomyocytes were reviewed in this paper.

Key words: Adult mesenchymal stem cells, Induction, Cardiomyocytes, Differentiation

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