组织工程与重建外科杂志

组织工程与重建外科杂志 ›› 2012, Vol. 8 ›› Issue (2): 110-113.doi: 10.3969/j.issn.1673-0364.2012.02.014

• 论著 • 上一篇    下一篇

生长因子在颅缝早闭症中作用的研究进展

唐冬生，韦敏   

  1. 上海交通大学医学院附属第九人民医院整复外科
  • 发布日期:2020-07-23

The Role of Growth Factors in Craniosynostosis

TANG Dongsheng,WEI Min   

  1. Department of Plastic and Reconstructive Surgery,Shanghai Ninth People’s Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 200011,China.
  • Published:2020-07-23

摘要： 颅缝早闭是一种较常见的先天性颅面畸形,表现为一条或多条颅缝过早闭合。多种因素可以在胚胎期及出生后影响头骨的发育,从而导致不同类型的颅缝早闭。目前研究表明,生长因子与颅缝闭合过程有着密切的联系,本文就生长因子在颅缝早闭症中作用的研究进展进行综述。

关键词: 颅缝早闭症, 成纤维细胞生长因子, 转化生长因子

Abstract: Craniosynostosis is a kind of common congenital craniofacial deformity,which represented the early close of one or more cranial sutures.Several factors can affect the growth of cranial vault during embryonic life and after birth,leading to different types of craniosynostosis.It has been showed that growth factors play crucial roles in cranial suture fusion.Research progress of growth factors in craniosynostosis is reviewed in this paper.

Key words: Craniosynostosis, FGFs, TGF-βs

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