组织工程与重建外科杂志

组织工程与重建外科杂志 >

2013 , Vol. 9 >Issue 5: 295 - 297

DOI: https://doi.org/10.3969/j.issn.1673-0364.2013.05.016

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骨髓间充质干细胞治疗椎间盘退行性病变的研究进展

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  • 同济大学附属上海第十人民医院骨科脊柱与微创中心

网络出版日期: 2020-07-23

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Research Progress of Bone Marrow Mesenchymal Stem Cells in Degenerated Intervertebral Disc

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  • Department of Orthopaedics, Shanghai Tenth People’s Hospital, Tongji University School of Medicine

Online published: 2020-07-23

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摘要

对椎间盘退变机制、BMSCs生物学特性、支架材料及细胞因子认识的深入,为BMSCs修复退变的椎间盘组织奠定了基础。研究表明,BMSCs治疗椎间盘退行性病变具有可行性,临床应用前景广阔。本文就BMSCs治疗椎间盘退行性病变的研究进展进行综述。

关键词： 组织工程; 骨髓间充质干细胞; 椎间盘; 退行性改变

本文引用格式

袁超群，张海龙 . 骨髓间充质干细胞治疗椎间盘退行性病变的研究进展[J]. 组织工程与重建外科杂志, 2013 , 9(5) : 295 -297 . DOI: 10.3969/j.issn.1673-0364.2013.05.016

Abstract

The further understanding of cellular scaffolds, cell factors, intervertebral disc (IVD) cell pathophysiology and BMSCs biology have laid the foundation of cell-based therapies for IVD degeneration. Moreover, a series of animal studies and vitro experiments also confirm the feasibility and effectiveness of cell-based therapies for IVD degeneration. It shows a wide prospect of clinical application in the future. The current research status of BMSCs in IVD tissue engineering was reviewed.

Key words： Tissue engineering; Bone marrow mesenchymal stem cells; Intervertebral disc; Degeneration

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