Journal of Tissue Engineering and Reconstructive Surgery ›› 2014, Vol. 10 ›› Issue (6): 355-362.doi: 10.3969/j.issn.1673-0364.2014.06.015

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Research Progress of Bone Morphogenetic Protein 2/7 Heterodimer

GAO Tao,ZHOU Lulu,MIAO Chunlei,TANG Shengjian,LIU Fangjun   

  1. Plastic Surgery Hospital, Weifang Medical University;
  • Published:2020-07-23
  • Contact: 国家自然科学基金资助项目(81372091)

Abstract: BMP2/7 heterodimer, a bone structure formation protein, has stronger osteogenesis inductive potential than its homodimer. So the study of BMP2/7 heterodimer has been one of the most important research directions in tissue engineering osteogenesis now. In this article, the osteo-inductive related experiments of BMP2/7 heterodimer were described, the differences of biological activity between heterodimer and homodimer were compared, and the mechanisms were overviewed.

Key words: Bone morphogenetic protein, Heterodimer, Bone tissue engineering, Osteogenic differentiation

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