Journal of Tissue Engineering and Reconstructive Surgery ›› 2009, Vol. 5 ›› Issue (4): 190-194.doi: 10.3969/j.issn.1673-0364.2009.08.003

• Original article • Previous Articles     Next Articles

Experimental Study of Immunogenicity of Tissue Engineering Materials by Using Humanized NOD/SCID Mice

ZHANG Qiuyu1,2,SHENG Huiming1,CUI Lei3,WANG Ying1,YING Shuo3,LIN Jinbiao1,WU Juanjuan1,SHEN Baihua WANG Li1,LI Ningli1   

  1. 1 Shanghai Jiaotong University School of Medicine;Shanghai Institute of Immunology;Shangh 200025;China. 2 Department of Immunology;Fujian Medical University;Fuzhou 350004;China. 3 Shanghai Tiss Engineering Research and Development Center;Shanghai 200235;China.;
  • Published:2020-07-23

Abstract: Objective To investigate the immunogenicity of new transplanted materials in vivo by using humanize NOD/SCID mice model. Methods humanized mice model was established by transferred 100×106 human peripheral blo mononuclear cells (PBMC) into NOD/SCID mice. Next day, the mice were received the allotransplantation of pieces of huma skin from plastic surgery patients as positive control group and received tissue engineering materials (silica ge accompanying with human adipose -derived stem cells (ADSCs) as exper...

Key words: NOD/SCID mice, Immunogenicity, Tissue engineering material

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