Abstract: Objective To explore the effects of Remifentanyl combined with Midazolam on sedation and analgesia in liposuction under tumescent anesthesia.Methods Thirty selective patients(ASAⅠ-Ⅱ) were treated by liposuction under tumescent anesthesia.All the patients were given Midazolam 0.3 mg/Kg + Remifentanyl 0.6 μg/Kg·min through venous for 30 seconds as loaded dose before tumescent anesthesia,then Remifentanyl at the rate of 0.1-0.3 μg/Kg·min was infused through venous pump.The Ramsay and VAS for scoring at the point before anesthesia(T0),the point before given the tumescent fluid(T1),the point of given the tumescent fluid(T2),the point of the beginning of liposuction(T3),the ending point of liposuction(T4),and 30 minutes after the liposuction(T5) were all recorded.The change of hemodynamic during anesthesia and liposuction as well as incidence were observed and recorded.Results The VAS grades were lower less than 5 in all patients.Compared with T0,the patients'' Ramsay grades,HR,SBP,DBP were higher(P<0.05),RR were lower(P<0.05).There was no significant difference at T2-T5(P >0.05).Two patients had the symptom like drowsiness and respiratory depression(RR<8 times/min) and SpO2 declined to 90%,while the SpO2 could recover to the normal level by the instruction ventilation and decreasing the volume of Remifentanyl.Conclusion Effective sedation and analgesia can be accomplished by using Remifentanyl combined with Midazolam in liposuction under tumescent anesthesia.The recovering time for recovery could be shortening,so this method can be considered to develop in daytime abdominal liposuction.

Key words: GetLinkList(KeywordFilter(''Remifentanyl, Midazolam, Tumescent anesthesia, Abdominal liposuction''),''kw'',''CJFQ'')