Abstract: Objective　To explore the clinical effect of Traditional Chinese Medicine (TCM) formula “JianpiQushi Fang” in the treatment of keloid in patients with phlegm-damp/damp-heat TCM constitution, and to provide preliminary clinical evidence for TCM systemic treatment of keloid. Methods　Twenty-five keloid cases were diagnosed as phlegm-dampness/damp heat constitution by TCM constitution criteria. The patients were treated with“JianpiQushi” decoction with 1 dose daily (half dose twice a day) and continued for 4 weeks as a course of treatment. Physique score, local scar pain/pruritus symptoms, and Vancouver scar scale (VSS) score were compared before and after the treatment. Results　Compared with before treatment, the physique score, scar local pain score and pruritus symptom score were significantly improved after treatment (P<0.05), while the scar VSS score had no significant change (P>0.05). Conclusion　“JianpiQushi Fang” can effectively reduce the symptoms of keloid in patients with phlegm-damp/damp-heat TCM constitution, but its effect on improving the appearance and texture of scar is limited, suggesting that it should be combined with local surgical treatment.

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