Journal of Tissue Engineering and Reconstructive Surgery ›› 2023, Vol. 19 ›› Issue (6): 597-.

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 Research progress of inhibiting cell aging in the treatment of cartilage regeneration in osteoarthritis

  

  • Published:2024-01-03

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Abstract:

In recent years, the role of cellular aging in the occurrence and development of osteoarthritis has become
a research hotspot. The existing evidence has basically confirmed that abnormal cartilage repair and the occurrence and
development of osteoarthritis (OA) have a causal relationship with chondrocyte aging and mesenchymal cells (MSCs) aging.
Targeted elimination of aging cells and promotion of the rejuvenation of stem cells can effectively delay OA. In this paper, the
pathological role of cellular aging in the occurrence and development of OA and potential therapeutic targets were reviewed. Cell
senescence is an important biological phenomenon and potential therapeutic target in the occurrence and development of OA.
Further study of its biological mechanism is helpful for the early prevention and treatment of OA.

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