Abstract: Objective To investigate the application of three-dimensional (3D) laser scan technology combined with MRI and CT examination in the measurement of craniofacial neurofibroma's volume.Methods From May 2015 to September 2016,11 patients with craniofacial neurofibroma were scanned by 3-D laser,MRI and CT.Mimics 18.0 software was used to reconstruct 3-D model of tumor and face,analyze and calculate 3-D model volume.All patients underwent 3-D laser scan again to evaluate the effects of the operation 3 months after operation.Results ① Volume of planned resection part was (61.8±67.5) cm3 according to MRI pre-operation.Volume of resected tumor was (47.0±55.4) cm3 during operation,accounting for (79.0％±16.4％) of the MRI volume.② The volume of the surgical head (bounded by the median line) was reduced to (54.4±60.5) cm3 scanned by 3-D laser,of which the reduction rate was (9.4％±6.4％).The actual volume reduction rate was (9.3％±5.8％) in terms of estimated in operation.There is no statistical significance (P=0.977) between two calculate methods.③ Based on the 3-D laser scan technology,the symmetry of the preoperative area (bounded by the median line) was (72.7％±1.1％),while it turned out to become (79.9％±9.3％) after operation.The degree of symmetry increased (10.6％±8.1％) with statistical significance (P=0.000 4).Conclusion 3-D laser scan technology is an effective supplement to MRI and CT.It would probably become a low-cost,convenient,direct,objective and accurate method to measure the volume of craniofacial neurofibroma,which can be used in guiding the operation,assessing the results,and monitoring tumor variation after operation.

Key words: Neurofibroma, Three-dimensional laser scan technology, Digital medicine