Abstract: Lymphedema is pathological protein accumulation in the interstitial space caused by the dysfunction of lymphatic conveyance and the obstruction of lymphatic drainage, which seriously affects the life quality of patients. Vascularized lymph node transfer (VLNT) can significantly alleviate lymphedema volume and decrease the incidence of cellulitis, and has the initial promising safety and effectiveness. VLNT has become the preferred treatment for lymphedema at present, but its functional mechanisms are not fully understood. In this paper, the research progress of VLNT animal models was reviewed, aiming to provide animal model references for in-depth study of VLNT functional mechanisms and surgical procedures update.

Key words: Vascularized lymph node transfer, 　Lymphedema, 　Animal model, 　Mechanism