Abstract: Objective　To explore the role of ubiquinone in ischemic reperfusion injury  by rat dorsal flap model. Methods　A total of 120 healthy adult male SD rats were randomly divided into three groups: sham surgery group, experimental group and control group, with 40 rats in each group. A flap of 9.0 cm×6.0 cm was designed on the back of the rat and five of the six blood supply vessels were ligated, and the experimental group and the control group were molded. The experimental group received 50 mg/kg ubiquinone; The sham surgery group and the control group were given the same amount of cooking oil every day, and the gastric volume was 5 mL/kg per day. On the 1st, 3rd, 5th and 7th days after the model was established, 10 rats were randomly sacrificed in each group to observe the corresponding indicators: the flap survival rate, flap tissue HE staining, flap tissue SOD activity and MDA content. Results　The flap survival rate, flap tissue HE staining, flap tissue SOD activity and MDA content of flap tissue were statistically analyzed. The sham operation group was superior to the experimental group and the experimental group was superior to the control group at all time points (P<0.05) except for the MDA content of skin flap between the sham operation group and the experimental group on the 7th day (P>0.05). Conclusion　Ubiquinone can effectively alleviate ischemia-reperfusion injury of oversized flaps on the back of rats.

Key words: Flap transplantation, 　Ischemic reperfusion injury, 　Ubiquinone, 　Antioxidant, 　Superoxide dismutase, 　Malondialdehyde