Abstract: Objective　To explore the methods and effects of resection, repair and reconstruction of huge chest wall tumors. Methods　The data of 4 patients with huge chest wall tumors from July 2015 to January 2020 were retrospectively analyzed, including chondrosarcoma in 2 cases, giant cell tumor in 1 case, and metastasis of breast cancer in 1 case. All patients underwent extensive tumor resection and thoracic cavity was exposed after tumor resection. Two patients were reconstructed with patch and titanium mesh, and the incision was closed directly. One patient was repaired with patch and latissimus dorsi flap. One patient was reconstructed with patch, titanium mesh and latissimus dorsi flap. Results　One case of postoperative incision infection improved after debridement. All patients were followed up for 2-6 years, no tumor recurrence and metastasis were found. All patients had no abnormal breathing, dyspnea and other discomfort. Conclusion　It is difficult to resect the huge tumor in the chest wall. It is more reasonable and safe to choose the reconstruction method of patch and titanium mesh. The latissimus dorsi flap can achieve good results in repairing soft tissue defects. Paying attention to perioperative management and multidisciplinary participation can make patients achieve better curative effect.

Key words: Chest wall tumor, 　Resection, 　Reconstruction, 　Multidisciplinary, 　Perioperative period