Abstract:

Objective　To explore the complications of topical treatment in children with infantile hemangioma (IH), so as

to provide a framework for clinical decision-making. Methods　From 2011 to 2021, a total of 32 patients with IH were retrieved

from medical databases and were divided into 6 different treatment groups: intralesional glucocorticoids injection group, bleomycin

injection group, laser therapy group, topical β blockers group, cryotherapy group and radiotherapy group. Side effects and adverse

events of therapies were described and discussed. Results　Almost all treatments resulted in scar healing. Light complications such

as significant pain, edema, hyperpigmentation were more common in laser therapy group, whereas severe complications such as ul

ceration and dysplasia were more common in radiotherapy group and bleomycin injection group. The most promising and safe topical

treatment option was the topical β blockers. Conclusion　Therapeutic regimens for IH should be selected cautiously based on the

child’s age, the size and location of the lesion, the presence of complications and the implementation conditions.

Key words:

　Infantile hemangioma, 　Iatrogenic complications, 　Clinical decision-making