Infantile hemangioma (IH) is a benign tumor that occurs in infants and childhood. The pathogenesis of IH has

not been fully elucidated. Although the course of the disease is self-limiting, partial patients may have sequelae that affect the

aesthetics or normal function. NOTCH signaling is an evolutionarily conserved signaling pathway, that plays vital roles in many

physiological and pathological processes, such as cell differentiation, embryonic vascular development, tissue itself-renewal, the

occurrence of tumor and inflammation, and regulation of vascular function. Endothelial-to-mesenchymal transition (EndMT) is a

mechanism in which endothelial cells (ECs) lose their unique properties and acquire mesenchymal and stem cell-like characteristics under the influence of multiple factors. EndMT can be involved in a variety of pathologies, including embryonic development, malignant tumor invasion, and fibrotic disease. Recent findings have shown that inhibition of the NOTCH signaling pathway might accelerate the regression of IH and interfere with disease progression caused by EndMT. In this paper, the progression of endothelial-to-mesenchymal transition and NOTCH signaling pathway in IH were reviewed

　Infantile hemangioma, 　Endothelial-to-mesenchymal transition, 　NOTCH signaling pathway