Autologous fat grafting has been widely used in plastic surgery. However, the unstable volume retention rate has

always been a significant problem, which is fundamentally due to the inadequate understanding of the mechanism of cell survival

and regeneration after transplantation. Autophagy plays a vital role in metabolic adaptation, cell differentiation and apoptosis inhibition, and many advances have been made in autophagy after autologous fat grafting. This review focused on the autophagy ofadipocytes and adipose-derived stem cells and the relationship between autophagy and inflammation and vascular remodeling. It

turned out that autophagy was closely related to cell survival and regeneration after autologous fat grafting, and moderately promoting autophagy may postoperatively improve the volume retention rate.

Autophagy, 　Autologous fat grafting, 　Volume retention rate, 　Survival, 　Regeneration