Abstract:

Dermatofibrosarcoma protuberans （DFSP）， one of the most common skin sarcomas， lacks specific clinical

and radiological features and exhibits complex histopathology. It is characterized by slow and irregular infiltration of

surrounding tissues， and surgical resection is the primary treatment modality. Currently， DFSP presents clinical challenges in

terms of high misdiagnosis and recurrence rates， necessitating the development of specific diagnostic markers and effective

therapeutic targets. This article aimed to provide a comprehensive review of the latest molecular genetics advancements in

DFSP， with the goal of offering new insights for its diagnosis and treatment.

Key words:

Dermatofibrosarcoma protuberans, Molecular biology, Rearrangement, Mutation