Objective To investigate the clinical efficacy and safety of fluorescent light energy （FLE） combined with

comprehensive nursing intervention in treating chronic skin ulcers （CSUs）.Methods From October 2020 to March 2023，5patients with CSU were enrolled and treated with FLE combined with standardized comprehensive nursing intervention. Each

patient was debrided before treatment. The FLE system consists of Lumiheal® medical wound gel dressing （Hunan Klox

Pharmaceutical Co.， Ltd.） and mitochondrial photon therapy device （Hunan Klox Pharmaceutical Co.， Ltd.）.During treatment， freshly prepared Lumiheal® medical wound gel dressing was applied to the local skin lesion with a thickness of

about 2 mm， and then the mitochondrial photon therapy device （light power density≥40 mW/cm2 ） was adjusted to a distance

of 5 cm from the wound surface， and luminated for 5 minutes. FLE treatment was applied twice a week for 6 consecutive times

with comprehensive nursing intervention. The clinical efficacy， safety， and patient satisfaction of wound healing and tissue

remodeling were evaluated after the treatment. Results The healing rate of 5 patients was 100%， the satisfaction rate of

patients and their families was 100%， and no obvious adverse reactions were observed during treatment. Conclusion FLE

therapy combined with comprehensive nursing intervention can shorten the healing time of ulcers， reduce economic loss，

reduce overall medical expenses and improve patient satisfaction.

Skin ulcers, Fluorescent light energy, Nursing interventions, Effect evaluation