The simultaneous reconstruction of appearance and function following large-area skin defects remains an unresolved challenge in clinical practice. Although skin expansion technology has been widely employed in tissue repair and reconstruction， its development has stagnated， primarily due to low expansion efficiency， high complication rates， and poorly understood mechanisms. To address this issue， an innovative approach utilizing acellular dermal matrix was proposed to assist in skin expansion and achieved promising preliminary clinical results. Acellular dermal matrix provides a “biocompatible” interface， balances mechanical forces， and serves as an active scaffold to support various cell types. However， its specific mechanism of action during the skin expansion process warrants further investigation. By acting as an expansion companion， acellular dermal matrix synergistically enhances skin expansion and holds the potential to break through current expansion limitations， thereby unlocking the full potential of skin expansion technology.

Skin expansion, Acellular dermal matrix, Dermis regeneration, Mechanical stretch