Calcification and absorption of the costal cartilage play an important role in ear reconstruction surgery，affecting the shape and stability of the ear. With the continuous development of medical technology， proteomics， as a new

research field， has been gradually applied to explore the molecular mechanism of costal cartilage calcification and absorption.At present， although some studies have revealed the potential of proteomics in the analysis of costal cartilage calcification and absorption， relevant studies are still in the initial stage， and there are problems such as small sample size， diversified research methods and poor repeatability of results. The purpose of this article is to review the latest research progress of the analysis for costal cartilage calcification and absorption based on proteomics， and to discuss its specific application in ear reconstruction surgery， in order to provide valuable reference and guidance for clinical practice.

 , Proteomics, Costal cartilage, Calcification, Absorption, Ear reconstruction surgery