Objective To evaluate the psychological outcomes associated with non-surgical treatment combined with health education in patients with facial keloids. Methods A prospective longitudinal cohort study was conducted with 61 consecutively enrolled patients undergoing multimodal non-surgical therapy， including procedural modalities （laser therapy， intralesional corticosteroid injections， radiation therapy and patient education） between January 2023 and April 2024. A triphasic assessment protocol was implemented， featuring semi-structured interviews via Generalized Anxiety Disorder-7 （GAD-7）， Patient Health Questionnaire-9（PHQ-9）， Modified Vancouver Scar Scale （MVSS）， Social Impact Scale （SIS）， General Self-Efficacy Scale （GSES） and Health Literacy Inventory at baseline， mid-treatment （week 4）， and one-month post-treatment，to assess the degree of anxiety and depression， scar status， social influence， self-efficacy and health knowledge acquisition. Results During the treatment process， the patient experienced a psychological transformation from low self-esteem and anxiety to gradually regaining confidence and facing life positively. Scores of GAD-7， PHQ-9， MVSS and SIS were significantly lower after treatment （P<0.05）. The score of GSES and rates of health knowledge acquisition were significantly higher than those before treatment （P<0.05）. Conclusion The non-surgical treatment combined with health education exerts a progressive effect of “appearance improvement-cognitive reconstruction-social adaptation”， which not only optimizes facial appearance but also improves psychological status， providing a theoretical basis for clinical formulation  of targeted psychological intervention strategies.

Keloid, Non-surgical treatment, Health education, Psychological health