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The Effect of Subpopulations of Dermal Skin Fibroblastsin in Skin Regeneration and Maintaining Homeostasis

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  • Department of Plastic and Reconstructive Surgery,Shanghai Ninth People's Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 200011,China)

Received date: 2018-11-03

  Revised date: 2018-12-20

  Online published: 2019-02-20

Abstract

Dermal fibroblasts divide into distinct subpopulation lineages:papillary fibroblasts(Fp)in superficial dermis layer,and reticular fibroblasts(Fr)in deep dermis layer.The two lineages have differences not only in cell functions and differentiation potentials,but also in wound healing,hair follicle formation,neogenesis,and skin senescence.In this paper,the differences of cell morphology,function,source,differentiation,specific expression between the two lineages,and their role in skin regeneration and maintaining homeostasis were all reviewed.

Cite this article

TAN Pohching,ZHOU Shuangbai,LI Qingfeng . The Effect of Subpopulations of Dermal Skin Fibroblastsin in Skin Regeneration and Maintaining Homeostasis[J]. Journal of Tissue Engineering and Reconstructive Surgery, 2019 , 15(1) : 49 -51 . DOI: 10.3969/j.issn.1673-0364.2019.01.014

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