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Craniosynostosis and FGF Signaling Pathway

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  • Key Laboratory of Resource Biology and Biotechnology in Western China of the Education Ministry,Northwest University

Online published: 2020-07-23

Abstract

Craniosynostosis represents a kind of skull deformity caused by the premature fusion of one or more cranial sutures,which often changes the patient's appearance,sometimes obstructs the normal development.Although the exact pathogenesis of early cranial suture closure is still largely unknown,the fibroblast epidermal growth factor (FGF) seems to have affected the normal development of the cranial sutures.In this paper,the recent genetic researches related craniosynostosis and those identified pathogenic genes were summarized,mainly focuses on the FGF factors,to help the genetic diagnosis and the study of cranial sutures defects.

Cite this article

LI Guoqing,KOU Yao,CHENG Mingjin,XU Sheng,TIAN Jing . Craniosynostosis and FGF Signaling Pathway[J]. Journal of Tissue Engineering and Reconstructive Surgery, 2017 , 13(4) : 215 -219 . DOI: 10.3969/j.issn.1673-0364.2017.04.011

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