Journal of Tissue Engineering and Reconstructive Surgery ›› 2017, Vol. 13 ›› Issue (4): 215-219.doi: 10.3969/j.issn.1673-0364.2017.04.011
• Review • Previous Articles Next Articles
LI Guoqing,KOU Yao,CHENG Mingjin,XU Sheng,TIAN Jing
Published:
Contact:
Abstract: Craniosynostosis represents a kind of skull deformity caused by the premature fusion of one or more cranial sutures,which often changes the patient's appearance,sometimes obstructs the normal development.Although the exact pathogenesis of early cranial suture closure is still largely unknown,the fibroblast epidermal growth factor (FGF) seems to have affected the normal development of the cranial sutures.In this paper,the recent genetic researches related craniosynostosis and those identified pathogenic genes were summarized,mainly focuses on the FGF factors,to help the genetic diagnosis and the study of cranial sutures defects.
Key words: Craniosynostosis, Pathogenic genes, Inheritance pattern, Fibroblast growth factors
CLC Number:
R726.2
LI Guoqing,KOU Yao,CHENG Mingjin,XU Sheng,TIAN Jing. Craniosynostosis and FGF Signaling Pathway[J]. Journal of Tissue Engineering and Reconstructive Surgery, 2017, 13(4): 215-219.
0 / / Recommend
Add to citation manager EndNote|Ris|BibTeX
URL: https://www.qk.sjtu.edu.cn/jter/EN/10.3969/j.issn.1673-0364.2017.04.011
https://www.qk.sjtu.edu.cn/jter/EN/Y2017/V13/I4/215