Review

Progress of Skin Substitutes for Regenerating Appendages

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  • 1 MOE Key Laboratory of Macromolecular Synthesis and Functionalization,Department of Polymer Science and Engineering, Zhejiang University,Hangzhou 310027,China;2 State Key Laboratory of Molecular Engineering of Polymers,Fudan University,Shanghai200000,China.Corresponding author:MA Lie E-mail:liema@zju.edu.cn).

Online published: 2020-07-23

Abstract

It is still an urgent problem to regenerate and repair skin defects in clinic. Up to now, even though a lot of skin substitutes have been developed and realize the clinical application, most of them can only repair the structure of epidermis and simple dermis. The reconstructive skin tissue can't reconstruct the functions of normal skin, usually due to the lack of skin appendages, such as hair follicles, sweat glands and sebaceous glands. In this paper, from the aspects of seed cells, scaffold materials and its bioactivation, the skin substitutes with the ability of regenerating skin appendages, especially hair follicles were reviewed. Finally, some important challenges for the future studies in this field were discussed.

Cite this article

LI Luyan,ZHANG Bing,LI Xiuyuan,MA Lie . Progress of Skin Substitutes for Regenerating Appendages[J]. Journal of Tissue Engineering and Reconstructive Surgery, 2016 , 12(5) : 313 -330 . DOI: 10.3969/j.issn.1673-0364.a458

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