Journal of Tissue Engineering and Reconstructive Surgery ›› 2016, Vol. 12 ›› Issue (5): 313-330.doi: 10.3969/j.issn.1673-0364.a458

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Progress of Skin Substitutes for Regenerating Appendages

LI Luyan1,ZHANG Bing1,LI Xiuyuan1,MA Lie1,2   

  1. 1 MOE Key Laboratory of Macromolecular Synthesis and Functionalization,Department of Polymer Science and Engineering, Zhejiang University,Hangzhou 310027,China;2 State Key Laboratory of Molecular Engineering of Polymers,Fudan University,Shanghai200000,China.Corresponding author:MA Lie
  • Published:2020-07-23
  • Contact: 国家重点基础研究发展计划(973)项目(2011CB606203);国家自然科学基金项目(51322302)。

Abstract: It is still an urgent problem to regenerate and repair skin defects in clinic. Up to now, even though a lot of skin substitutes have been developed and realize the clinical application, most of them can only repair the structure of epidermis and simple dermis. The reconstructive skin tissue can't reconstruct the functions of normal skin, usually due to the lack of skin appendages, such as hair follicles, sweat glands and sebaceous glands. In this paper, from the aspects of seed cells, scaffold materials and its bioactivation, the skin substitutes with the ability of regenerating skin appendages, especially hair follicles were reviewed. Finally, some important challenges for the future studies in this field were discussed.

Key words: Hair follicles, Sweat glands, Sebaceous glands, Skin substitutes, Biomaterials

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