Journal of Tissue Engineering and Reconstructive Surgery >

2014 , Vol. 10 >Issue 4: 181 - 186

DOI: https://doi.org/10.3969/j.issn.1673-0364.2014.04.001

Original article

The Influence of Propranolol on VEGF, bFGF, MMP-9 in Serum Samples in the Treatment Proliferative Hemangioma

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  • Department of Plastic Surgery,the First Affiliated Hospital of Fujian Medical University;

Online published: 2020-07-23

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Abstract

Objective To investigate the influence of propranolol on VEGF, bFGF and MMP-9 in serum samples in the treatment of proliferative hemangioma. Methods Forty children with proliferative hemangioma were enrolled and treated with propranolol. The VEGF, bFGF and MMP-9 in serum samples were detected with ELISA assay before and 8 weeks after propranolol treatment. Results After 8 weeks of treatment, the concentration levels of VEGF, bFGF and MMP-9 in serum were obviously decreased, and the differences were significant. Conclusion The decrease on the expression of VEGF, bFGF and MMP-9 may play an important role in the treatment of proliferative hemangioma.

Key words： Propranolol; Infantile hemangioma; Vascular endothelial growth factor; Basic fibroblast growth factor; Matrix metalloproteinase-9

Cite this article

WU Shanying,WANG Biao,CHEN Lifen,HUANG Zugen,HUANG Xunlei,WANG Meishui . The Influence of Propranolol on VEGF, bFGF, MMP-9 in Serum Samples in the Treatment Proliferative Hemangioma[J]. Journal of Tissue Engineering and Reconstructive Surgery, 2014 , 10(4) : 181 -186 . DOI: 10.3969/j.issn.1673-0364.2014.04.001

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