The Influence of Propranolol on VEGF, bFGF, MMP-9 in Serum Samples in the Treatment Proliferative Hemangioma

doi:10.3969/j.issn.1673-0364.2014.04.001

Abstract

Abstract: Objective To investigate the influence of propranolol on VEGF, bFGF and MMP-9 in serum samples in the treatment of proliferative hemangioma. Methods Forty children with proliferative hemangioma were enrolled and treated with propranolol. The VEGF, bFGF and MMP-9 in serum samples were detected with ELISA assay before and 8 weeks after propranolol treatment. Results After 8 weeks of treatment, the concentration levels of VEGF, bFGF and MMP-9 in serum were obviously decreased, and the differences were significant. Conclusion The decrease on the expression of VEGF, bFGF and MMP-9 may play an important role in the treatment of proliferative hemangioma.

Key words: Propranolol, Infantile hemangioma, Vascular endothelial growth factor, Basic fibroblast growth factor, Matrix metalloproteinase-9

CLC Number:

R732.2

WU Shanying,WANG Biao,CHEN Lifen,HUANG Zugen,HUANG Xunlei,WANG Meishui. The Influence of Propranolol on VEGF, bFGF, MMP-9 in Serum Samples in the Treatment Proliferative Hemangioma[J]. Journal of Tissue Engineering and Reconstructive Surgery, 2014, 10(4): 181-186.

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The Influence of Propranolol on VEGF, bFGF, MMP-9 in Serum Samples in the Treatment Proliferative Hemangioma

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