Objective To provide useful reference for the pre-operative design and post-operative estimation by pre-operation 3D scanning and simulation in nasal reconstruction. Methods Facial scans of normal crowd and patients with nasal defect were acquired, then nasal region fitting patients' facial contour was simulated. Simulated nose were measured by computer to provide valuable information for nasal reconstruction. The data of simulation and postoperative result were compared and analyzed. Results 3D scanning and simulating technique proved to be helpful in providing useful data such as flap area and dimensions of anatomical parts for nasal reconstruction surgery. Statistical analysis showed no difference between the data of simulation and postoperative result. Conclusion 3D scanning and simulation could assist the pre-operative and post-operative estimation for nasal reconstruction, and play a great role in improving operative effect and patients’ satisfaction.