Nowadays the main problem in tissue engineering both in vitro and in vivo is the lack of sufficient blood supply - the vascularization. There are two main current strategies to create vascularized tissues. The first strategy is based on the cells and their ability to form new vessels. In this process growth factors as well as cells are contribute to generate new vessels. The second strategy is scaffold based techniques, including naturally -derived scaffolds and synthetically manufactured scaffolds. Future strategies to create vascularized tissues were reviewed.